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3-Nitrocoumarin

Name: 3-Nitrocoumarin
Brand: TargetMol
SKU: T10115
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10115Cas No. 28448-04-6

Alias 3-nitrochromen-2-one

3-Nitrocoumarin (3-nitrochromen-2-one) (3-NC) is a potent and selective Phospholipase C-γ (PLCγ) inhibitor.

3-Nitrocoumarin

🥰Excellent

Purity: 99.85%

Catalog No. T10115Alias 3-nitrochromen-2-oneCas No. 28448-04-6

3-Nitrocoumarin (3-nitrochromen-2-one) (3-NC) is a potent and selective Phospholipase C-γ (PLCγ) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	-	In Stock
5 mg	$52	-	In Stock
10 mg	$89	-	In Stock
25 mg	$182	-	In Stock
50 mg	$318	-	In Stock
100 mg	$455	-	In Stock
1 mL x 10 mM (in DMSO)	$58	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Questions

Batch Information

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Purity:99.85%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	3-Nitrocoumarin (3-nitrochromen-2-one) (3-NC) is a potent and selective Phospholipase C-γ (PLCγ) inhibitor.
Synonyms	3-nitrochromen-2-one

Chemical Properties

Molecular Weight	191.14
Formula	C₉H₅NO₄
Cas No.	28448-04-6
Smiles	[O-][N+](=O)c1cc2ccccc2oc1=O
Relative Density.	1.48 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (470.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2318 mL	26.1588 mL	52.3177 mL	261.5884 mL
5 mM	1.0464 mL	5.2318 mL	10.4635 mL	52.3177 mL
10 mM	0.5232 mL	2.6159 mL	5.2318 mL	26.1588 mL
20 mM	0.2616 mL	1.3079 mL	2.6159 mL	13.0794 mL
50 mM	0.1046 mL	0.5232 mL	1.0464 mL	5.2318 mL
100 mM	0.0523 mL	0.2616 mL	0.5232 mL	2.6159 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc