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Tetramethylthiuram monosulfide
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Catalog No. T22438Cas No. 97-74-5
Alias TMTM
Tetramethylthiuram monosulfide is widely used as a catalyst in rubber-processing techniques, it possesses a medium-degree toxicity and causes point mutations in strains TA 100 and TA 1535 (Salmonella typhimurium LT 2).
Tetramethylthiuram monosulfide
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Purity: 99.8%
Catalog No. T22438Alias TMTMCas No. 97-74-5
Tetramethylthiuram monosulfide is widely used as a catalyst in rubber-processing techniques, it possesses a medium-degree toxicity and causes point mutations in strains TA 100 and TA 1535 (Salmonella typhimurium LT 2).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $41 | In Stock | In Stock | |
| 500 mg | $100 | In Stock | In Stock | |
| 1 g | $147 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.8%
Appearance:Solid
Color:Yellow
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Product Introduction
Tetramethylthiuram monosulfide AI Summary
Tetramethylthiuram monosulfide exhibits diverse bioactivities across multiple biological targets and assays. It significantly inhibits human monoglyceride lipase (MGL) activity, with over 50% inhibition at 10 µM concentration and an IC50 value of 12302.69 nM, while showing negligible inhibition on human recombinant fatty acid amide hydrolase (FAAH) with an IC50 value above 1000000.0 nM. In various assays, it displays potencies ranging from 28.2 nM (as an agonist of glucocorticoid receptor signaling) to over 70794.6 nM (as an activator of the human pregnane X receptor (PXR) signaling pathway). It demonstrates antiviral activities by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, and inhibits SARS-CoV-2 3CL-Pro protease with 99.73% inhibition at 20 µM and an IC50 value of 940.0 nM. Additionally, it shows antitrichomonas activity against metronidazole-susceptible and resistant Trichomonas vaginalis and has antifungal activity against several fungal strains including Cryptococcus neoformans. Tetramethylthiuram monosulfide also inhibits human HDAC6 with 16.13% and 12.25% inhibition in enzymatic assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tetramethylthiuram monosulfide is widely used as a catalyst in rubber-processing techniques, it possesses a medium-degree toxicity and causes point mutations in strains TA 100 and TA 1535 (Salmonella typhimurium LT 2). |
| Synonyms | TMTM |
| Molecular Weight | 208.37 |
| Formula | C6H12N2S3 |
| Cas No. | 97-74-5 |
| Smiles | CN(C)C(=S)SC(=S)N(C)C |
| Relative Density. | 1.255g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 3 mg/mL (14.4 mM), Sonication is recommended. DMSO: 50 mg/mL (239.96 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.6 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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