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Clomazone

Name: Clomazone
Brand: TargetMol
SKU: T19781
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19781Cas No. 81777-89-1

Alias Magister, Gamit, FMC 57020, Dimethazone, Command

Clomazone (Magister) is an agricultural herbicide. The molecule consists of a 2-chlorobenzyl group bound to an N-O heterocycle called Isoxazole. Clomazone suppresses the biosynthesis of chlorophyll and other plant pigments.

Clomazone

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Purity: 99.26%

Catalog No. T19781Alias Magister, Gamit, FMC 57020, Dimethazone, CommandCas No. 81777-89-1

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$42	In Stock	In Stock
100 mg	$66	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.26%

Appearance:Solid

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COA LCMS HNMR

Product Introduction

Clomazone AI Summary

Clomazone inhibits human FAAH at a concentration of 1 µM with 24.73% inhibition. It acts as a small molecule agonist for several receptors: androgen receptor signaling with a potency of 112201.8 nM, vitamin D receptor signaling with a potency of 4.5 nM, human pregnane X receptor (PXR) signaling pathway with a potency of 12589.3 nM, and antioxidant response element (ARE) signaling pathway measured by Nrf2-dependent transcriptional activity with a potency of 68589.6 nM. Additionally, Clomazone displays phytotoxic activities on Phaseolus vulgaris (beans), affecting crop injury, yield, shoot dry weight, and plant height, depending on dosage and timing. Specifically, it increases crop yield when applied at 1000 g ai/ha during pre-emergence treatment, achieving a yield of 4.5 tons/ha compared to 4.1 tons/ha at a higher dose. However, it also causes phytotoxic effects, such as decreased shoot dry weight, plant height, and increased visual injury percentages at both 1000 g ai/ha and 2000 g ai/ha dosages, indicating its impact on the growth and development of Phaseolus vulgaris..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Clomazone (Magister) is an agricultural herbicide. The molecule consists of a 2-chlorobenzyl group bound to an N-O heterocycle called Isoxazole. Clomazone suppresses the biosynthesis of chlorophyll and other plant pigments.
Synonyms	Magister, Gamit, FMC 57020, Dimethazone, Command

Chemical Properties

Molecular Weight	239.7
Formula	C₁₂H₁₄ClNO₂
Cas No.	81777-89-1
Smiles	CC1(C)CON(Cc2ccccc2Cl)C1=O
Relative Density.	1.192

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (1022.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1719 mL	20.8594 mL	41.7188 mL	208.5941 mL
5 mM	0.8344 mL	4.1719 mL	8.3438 mL	41.7188 mL
10 mM	0.4172 mL	2.0859 mL	4.1719 mL	20.8594 mL
20 mM	0.2086 mL	1.0430 mL	2.0859 mL	10.4297 mL
50 mM	0.0834 mL	0.4172 mL	0.8344 mL	4.1719 mL
100 mM	0.0417 mL	0.2086 mL	0.4172 mL	2.0859 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc