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LPA5 antagonist 2

Name: LPA5 antagonist 2
Brand: TargetMol
SKU: T63172
Price: 1520 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63172 Copy Product Info

Purity: 99.82%

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LPA5 antagonist 2 is a highly water-soluble, selective antagonist of the lysosomal phosphatidic acid receptor 5 (LPA5) that inhibits downstream calcium mobilization (IC₅₀ = 69 nM) and cAMP signaling (IC₅₀ = 340 nM) by blocking the binding of its natural ligand, LPA. LPA5 antagonist 2 significantly alleviates CFA-induced inflammatory pain and nociceptive hypersensitivity and can be used in research related to inflammatory and neuropathic pain.

Cas No. 2839471-44-0

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,520	-	In Stock
50 mg	$1,980	-	In Stock
100 mg	$2,500	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.82%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

LPA5 antagonist 2 (0-10 μM) inhibits hLPA5 calcium mobilization with an IC50 value of 69 nM and inhibits hLPA5 cAMP with an IC50 value of 340 nM.[1]
LPA5 antagonist 2 (0-10 μM) shows no significant affinity for other receptors, exhibits good target selectivity for LPA5.[1]

Chemical Properties

Molecular Weight	480.55
Formula	C₂₆H₂₅FN₂O₄S
Cas No.	2839471-44-0
Smiles	O=C1C=2C=C(OC)C(OC)=CC2C(=CN1C=3C=CC=4SC=C(C4C3)C)C(=O)N5CCC(F)CC5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (166.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0809 mL	10.4047 mL	20.8095 mL	104.0474 mL
5 mM	0.4162 mL	2.0809 mL	4.1619 mL	20.8095 mL
10 mM	0.2081 mL	1.0405 mL	2.0809 mL	10.4047 mL
20 mM	0.1040 mL	0.5202 mL	1.0405 mL	5.2024 mL
50 mM	0.0416 mL	0.2081 mL	0.4162 mL	2.0809 mL
100 mM	0.0208 mL	0.1040 mL	0.2081 mL	1.0405 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: LPA5 antagonist 2 chemical structure | LPA5 antagonist 2 in vitro | LPA5 antagonist 2 formula | LPA5 antagonist 2 molecular weight