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EIDD-2749

🥰Excellent
Catalog No. T73253Cas No. 1613589-24-4
Alias 4'-Fluorouridine, 4'-FlU

EIDD-2749 (4'-FlU), a ribonucleoside analog, is an orally available RdRp inhibitor with spectroscopic antiviral activity that interrupts the replication of respiratory syncytial virus and SARS-CoV-2.EIDD-2749 attenuates lethal infections of pandemic human and highly pathogenic avian influenza viruses.

EIDD-2749

EIDD-2749

🥰Excellent
Purity: 97.39%
Catalog No. T73253Alias 4'-Fluorouridine, 4'-FlUCas No. 1613589-24-4
EIDD-2749 (4'-FlU), a ribonucleoside analog, is an orally available RdRp inhibitor with spectroscopic antiviral activity that interrupts the replication of respiratory syncytial virus and SARS-CoV-2.EIDD-2749 attenuates lethal infections of pandemic human and highly pathogenic avian influenza viruses.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$98In StockIn Stock
10 mg$180In StockIn Stock
25 mg$392In StockIn Stock
50 mg$748-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:97.39%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
EIDD-2749 (4'-FlU), a ribonucleoside analog, is an orally available RdRp inhibitor with spectroscopic antiviral activity that interrupts the replication of respiratory syncytial virus and SARS-CoV-2.EIDD-2749 attenuates lethal infections of pandemic human and highly pathogenic avian influenza viruses.
In vitro
EIDD-2749 (20 uM) is effective in synthesizing metabolism in HAE cells and is effective on human airway epithelial organoids[1].
In vivo
In Balb/cJ mice (RSV infection model), EIDD-2749 (0.2, 1, 5 mg/kg; oral administration; once daily for 4 days) resulted in a statistically significant reduction in lung virus load[1].
Synonyms4'-Fluorouridine, 4'-FlU
Chemical Properties
Molecular Weight262.19
FormulaC9H11FN2O6
Cas No.1613589-24-4
SmilesO[C@H]1[C@@H](O[C@@](CO)(F)[C@H]1O)N2C(=O)NC(=O)C=C2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 15 mg/mL (57.21 mM), Sonication is recommended.
H2O: 50 mg/mL (190.7 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.63 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM3.8140 mL19.0701 mL38.1403 mL190.7014 mL
5 mM0.7628 mL3.8140 mL7.6281 mL38.1403 mL
10 mM0.3814 mL1.9070 mL3.8140 mL19.0701 mL
20 mM0.1907 mL0.9535 mL1.9070 mL9.5351 mL
50 mM0.0763 mL0.3814 mL0.7628 mL3.8140 mL
H2O
1mg5mg10mg50mg
100 mM0.0381 mL0.1907 mL0.3814 mL1.9070 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SARS-CoV-2SARSCoVEIDD-2749EIDD2749EIDD 2749Antiviral4'-FlU ; 4'-Fluorouridine
Related Tags: buy EIDD-2749 | purchase EIDD-2749 | EIDD-2749 cost | order EIDD-2749 | EIDD-2749 chemical structure | EIDD-2749 in vivo | EIDD-2749 in vitro | EIDD-2749 formula | EIDD-2749 molecular weight
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