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MK-0941

Name: MK-0941
Brand: TargetMol
SKU: T12057
Rating: 4.5 (1 reviews)

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Catalog No. T12057Cas No. 1137916-97-2

MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.

MK-0941

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🥰Excellent

Catalog No. T12057Cas No. 1137916-97-2

MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.

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Product Introduction

Bioactivity

Description	MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.
Targets&IC50	GK (human recombinant):65 nM (EC50), GK (human recombinant):240 nM (EC50)

Chemical Properties

Molecular Weight	556.61
Formula	C₂₂H₂₈N₄O₉S₂
Cas No.	1137916-97-2
Smiles	CS(O)(=O)=O.CCS(=O)(=O)c1ccc(Oc2cc(O[C@@H](C)CO)cc(c2)C(=O)Nc2ccn(C)n2)cn1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (467.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7966 mL	8.9830 mL	17.9659 mL	89.8295 mL
5 mM	0.3593 mL	1.7966 mL	3.5932 mL	17.9659 mL
10 mM	0.1797 mL	0.8983 mL	1.7966 mL	8.9830 mL
20 mM	0.0898 mL	0.4491 mL	0.8983 mL	4.4915 mL
50 mM	0.0359 mL	0.1797 mL	0.3593 mL	1.7966 mL
100 mM	0.0180 mL	0.0898 mL	0.1797 mL	0.8983 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc