MK-0941

Name: MK-0941
Brand: TargetMol
SKU: T12057
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T12057Cas No. 1137916-97-2

MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.

MK-0941

🥰Excellent

Catalog No. T12057Cas No. 1137916-97-2

MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.

Product information is being updated, if you want to purchase, please click the bulk custom button.

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Product Introduction

Bioactivity

Description	MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.
Targets&IC50	GK (human recombinant):65 nM (EC50), GK (human recombinant):240 nM (EC50)

Chemical Properties

Molecular Weight	556.61
Formula	C₂₂H₂₈N₄O₉S₂
Cas No.	1137916-97-2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (467.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7966 mL	8.9830 mL	17.9659 mL	89.8295 mL
5 mM	0.3593 mL	1.7966 mL	3.5932 mL	17.9659 mL
10 mM	0.1797 mL	0.8983 mL	1.7966 mL	8.9830 mL
20 mM	0.0898 mL	0.4491 mL	0.8983 mL	4.4915 mL
50 mM	0.0359 mL	0.1797 mL	0.3593 mL	1.7966 mL
100 mM	0.0180 mL	0.0898 mL	0.1797 mL	0.8983 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc