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Pomalidomide-PEG2-CO2H

Name: Pomalidomide-PEG2-CO2H
Brand: TargetMol
SKU: T40025
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40025Cas No. 2140807-17-4

Alias Pomalidomide-PEG2-C2-acid, Pomalidomide 4'-PEG2-acid

Pomalidomide-PEG2-CO2H is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker.

Pomalidomide-PEG2-CO2H

🥰Excellent

Purity: 99.25%

Catalog No. T40025Alias Pomalidomide-PEG2-C2-acid, Pomalidomide 4'-PEG2-acidCas No. 2140807-17-4

Pomalidomide-PEG2-CO2H is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker.

Pack Size	Price	Availability
5 mg	$60	In Stock
10 mg	$88	In Stock
25 mg	$147	In Stock
50 mg	$263	In Stock
100 mg	$385	In Stock
200 mg	$576	In Stock

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Batch Information

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Purity:99.25%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Pomalidomide-PEG2-CO2H is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker.
In vitro	PROTACs contain two distinct ligands, one for the E3 ubiquitin ligase and the other for the target protein, linked by a linker[1].
Synonyms	Pomalidomide-PEG2-C2-acid, Pomalidomide 4'-PEG2-acid

Chemical Properties

Molecular Weight	433.41
Formula	C₂₀H₂₃N₃O₈
Cas No.	2140807-17-4
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCC(O)=O
Relative Density.	1.456 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (461.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3073 mL	11.5364 mL	23.0728 mL	115.3642 mL
5 mM	0.4615 mL	2.3073 mL	4.6146 mL	23.0728 mL
10 mM	0.2307 mL	1.1536 mL	2.3073 mL	11.5364 mL
20 mM	0.1154 mL	0.5768 mL	1.1536 mL	5.7682 mL
50 mM	0.0461 mL	0.2307 mL	0.4615 mL	2.3073 mL
100 mM	0.0231 mL	0.1154 mL	0.2307 mL	1.1536 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc