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PFKFB3-IN-2

Name: PFKFB3-IN-2
Brand: TargetMol
SKU: T67874
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67874Cas No. 794552-84-4

PFKFB3-IN-2 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). Anti-sense treatment against PFKFB3 has demonstrated a reduction in tumor growth rate in vivo.

PFKFB3-IN-2

🥰Excellent

Purity: 99.12%

Catalog No. T67874Cas No. 794552-84-4

PFKFB3-IN-2 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). Anti-sense treatment against PFKFB3 has demonstrated a reduction in tumor growth rate in vivo.

Pack Size	Price	Availability
5 mg	$45	In Stock
10 mg	$65	In Stock
25 mg	$112	In Stock
50 mg	$167	In Stock
100 mg	$236	In Stock
200 mg	$348	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock

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Batch Information

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Purity:99.12%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

PFKFB3-IN-2 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). Anti-sense treatment against PFKFB3 has demonstrated a reduction in tumor growth rate in vivo.

Chemical Properties

Molecular Weight	337.3
Formula	C₁₄H₁₁NO₇S
Cas No.	794552-84-4
Smiles	S(NC1=CC(O)=C(C(O)=O)C=C1)(=O)(=O)C2=CC(C(O)=O)=CC=C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (74.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9647 mL	14.8236 mL	29.6472 mL	148.2360 mL
5 mM	0.5929 mL	2.9647 mL	5.9294 mL	29.6472 mL
10 mM	0.2965 mL	1.4824 mL	2.9647 mL	14.8236 mL
20 mM	0.1482 mL	0.7412 mL	1.4824 mL	7.4118 mL
50 mM	0.0593 mL	0.2965 mL	0.5929 mL	2.9647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc