(R)-DOI hydrochloride is the salt form of 2,5-Dimethoxy-4-iodoamphetamine (DOI), a potent 5-HT2A and 5-HT2C receptor agonist, orally active and capable of producing hallucinogenic effects.

In vivo, intracerebroventricular infusion of (R)-DOI hydrochloride (dose not specified) in turkeys significantly increased plasma prolactin (PRL) levels (by 40% at 5 min post-infusion, peaking at 20 min). (R)-DOI hydrochloride also activated hypothalamic dopaminergic (TH-positive) and vasoactive intestinal peptide (VIP-positive) neurons, as indicated by c-fos mRNA expression co-localization (POM: 9.2%, PMM: 44.6%, ML: 28.6%; VIP neurons: 13.2%), suggesting its role in PRL regulation via neuronal activation[1].