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MRS1845

Name: MRS1845
Brand: TargetMol
SKU: T12108
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12108Cas No. 544478-19-5

MRS1845 is an ORAI1 inhibitor and calcium entry (SOCE) blocker that blocks VP-induced SOCE, OS, and Ca(2+) deposition.

MRS1845

🥰Excellent

Purity: 99.69%

Catalog No. T12108Cas No. 544478-19-5

MRS1845 is an ORAI1 inhibitor and calcium entry (SOCE) blocker that blocks VP-induced SOCE, OS, and Ca(2+) deposition.

Pack Size	Price	Availability	Quantity
1 mg	$48	In Stock
5 mg	Preferential	In Stock

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Purity:99.69%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MRS1845 is an ORAI1 inhibitor and calcium entry (SOCE) blocker that blocks VP-induced SOCE, OS, and Ca(2+) deposition.
In vitro	Additional treatment with the ORAI1 inhibitor MRS1845 (10 μM) actually disrupted the effect of β-glycerophosphate on SOCE. Furthermore, in the presence of the ORAI1 inhibitor and when ORAI1 was silenced, the expression and activity of β-glycerophosphate-induced MSX2, CBFA1, SOX9, and ALPL mRNA in HAoSMCs were inhibited[2].

Chemical Properties

Molecular Weight	398.41
Formula	C₂₁H₂₂N₂O₆
Cas No.	544478-19-5
Smiles	CCOC(=O)C1=C(C)N(CC#C)C(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC
Relative Density.	1.318g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 60 mg/mL (150.60 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5100 mL	12.5499 mL	25.0998 mL	125.4989 mL
5 mM	0.5020 mL	2.5100 mL	5.0200 mL	25.0998 mL
10 mM	0.2510 mL	1.2550 mL	2.5100 mL	12.5499 mL
20 mM	0.1255 mL	0.6275 mL	1.2550 mL	6.2749 mL
50 mM	0.0502 mL	0.2510 mL	0.5020 mL	2.5100 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2550 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc