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Z-VAD
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Catalog No. T89262Cas No. 162852-62-2
Z-VAD is an irreversible pan-caspase inhibitor capable of suppressing multiple caspases including caspase-3, -6, -7, -8, and -9. Z-VAD induces autophagy and necrosis in tumour cells, delays tumour growth, exhibits anti-angiogenic activity, and enhances the sensitivity of breast and lung cancer cells to radiotherapy.
Z-VAD
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Purity: 98.96%
Catalog No. T89262Cas No. 162852-62-2
Z-VAD is an irreversible pan-caspase inhibitor capable of suppressing multiple caspases including caspase-3, -6, -7, -8, and -9. Z-VAD induces autophagy and necrosis in tumour cells, delays tumour growth, exhibits anti-angiogenic activity, and enhances the sensitivity of breast and lung cancer cells to radiotherapy.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $691 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock | |
| 200 mg | $2,680 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.96%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Z-VAD is an irreversible pan-caspase inhibitor capable of suppressing multiple caspases including caspase-3, -6, -7, -8, and -9. Z-VAD induces autophagy and necrosis in tumour cells, delays tumour growth, exhibits anti-angiogenic activity, and enhances the sensitivity of breast and lung cancer cells to radiotherapy. |
| In vitro | After 24 hours of treatment with Z-VAD (50 μM), the sensitivity of MDA-MB-231 breast cancer cells and H460 lung cancer cells to ionizing radiation was significantly increased [1]. When Z-VAD (50 μM) was combined with radiotherapy (for 24 or 48 hours), it caused an increase in the number of autophagosomes in breast cancer and lung cancer cells and elevated the expression levels of autophagy-related proteins such as the ATG5-ATG12 complex and Beclin-1 [1]. The combined use of Z-VAD (50 μM) and radiotherapy significantly suppressed the formation of capillary-like tubular structures by Homo sapiens umbilical vein endothelial cells (HUVECs) and Broussonetia papyrifera [1]. |
| In vivo | Methods: Z-VAD (5 mg/kg, three times per week for 4 weeks) was administered via intraperitoneal injection to female BALB/c nude mice bearing transplanted tumors of MDA-MB-231 breast cancer or H460 lung cancer in the Parazacco spilurus subsp. spilurus species. Results: The combined application of Z-VAD and radiotherapy significantly inhibited tumor growth, and the mice exhibited good tolerance. |
| Molecular Weight | 437.44 |
| Formula | C20H27N3O8 |
| Cas No. | 162852-62-2 |
| Smiles | C(OC(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)C)=O)C(C)C)=O)C1=CC=CC=C1 |
| Sequence | Z-Val-Ala-Asp |
| Sequence Short | Z-VAD |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (91.44 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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