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HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (His & Avi), FITC-Labeled

Catalog No. TMPK-01443
Synonyms: KRAS1, C-K-RAS, K-RAS4B, RALD, K-Ras 2, K-RAS2A, K-RAS2B, KRAS2, NS3, KI-RAS, KRAS, RASK2, GTPase Kras, MHC, K-RAS4A, NS, CFC2

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (His & Avi), FITC-Labeled
Pack Size Availability Price/USD Quantity
100 μg Inquiry $ 219.00
1 mg Inquiry $ 1,469.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
Species Human
Expression System HEK293
Tag C-His-Avi
Accession Number AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGAVGVGK
Synonyms KRAS1, C-K-RAS, K-RAS4B, RALD, K-Ras 2, K-RAS2A, K-RAS2B, KRAS2, NS3, KI-RAS, KRAS, RASK2, GTPase Kras, MHC, K-RAS4A, NS, CFC2
Construction Recombinant FITC-Labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGAVGVGK peptide.[Accession |AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGAVGVGK]
Protein Purity > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin Less than 1EU per μg by the LAL method.
Formulation Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Stability & Storage

Valid for 12 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Research Background Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

References and Literature

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Keywords

HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (His & Avi), FITC-Labeled KRAS1 C-K-RAS K-RAS4B RALD K-Ras 2 K-RAS2A K-RAS2B KRAS2 NS3 KI-RAS KRAS RASK2 GTPase Kras MHC K-RAS4A NS CFC2 recombinant recombinant-proteins proteins protein

 

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