Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties.
Description | YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties. |
Targets&IC50 | PCAF:29.04 μM (EC50), GCN5:49.31 μM (EC50), CBP:2.75 μM (EC50) |
In vitro | YF-2, at concentrations ranging from 0.03 to 80 μM for 72 hours, effectively inhibits the proliferation of U251, CCRF-CEM, Hs578T, and NCI-ADR-RES cells[1]. |
In vivo | YF-2 administered intraperitoneally at a dosage of 20 mg/kg two hours before or at 5 mg/kg thirty minutes before an electric shock, ameliorates the impairment in contextual memory observed in mice. However, at a dosage of 20 mg/kg without preceding electric shock, YF-2 does not influence contextual memory in mice [1]. |
Molecular Weight | 467.31 |
Formula | C20H23Cl2F3N2O3 |
CAS No. | 1312005-62-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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