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ITH-12575

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Catalog No. T27639Cas No. 1802013-08-6
Alias ITH12575, ITH 12575

ITH-12575 is an inhibitor of the mitochondrial Na⁺/Ca²⁺ exchanger (mNCX) that modulates mitochondrial calcium homeostasis, and at low micromolar concentrations ITH-12575 reduces Ca²⁺ influx through CALHM1 channels, supporting its use in studies of mitochondrial signaling, neuronal excitability, calcium-dependent metabolism, and neurodegenerative disease mechanisms.

ITH-12575

ITH-12575

😃Good
Catalog No. T27639Alias ITH12575, ITH 12575Cas No. 1802013-08-6
ITH-12575 is an inhibitor of the mitochondrial Na⁺/Ca²⁺ exchanger (mNCX) that modulates mitochondrial calcium homeostasis, and at low micromolar concentrations ITH-12575 reduces Ca²⁺ influx through CALHM1 channels, supporting its use in studies of mitochondrial signaling, neuronal excitability, calcium-dependent metabolism, and neurodegenerative disease mechanisms.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$93235 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
ITH-12575 is an inhibitor of the mitochondrial Na⁺/Ca²⁺ exchanger (mNCX) that modulates mitochondrial calcium homeostasis, and at low micromolar concentrations ITH-12575 reduces Ca²⁺ influx through CALHM1 channels, supporting its use in studies of mitochondrial signaling, neuronal excitability, calcium-dependent metabolism, and neurodegenerative disease mechanisms.
In vitro
In models utilizing SH-SY5Y neuroblastoma cells and bovine chromaffin cells, ITH-12575 effectively mitigated cytotoxicity induced by Veratridine and high concentrations of potassium (K+). The compound prevented the rapid efflux of Ca2+ from mitochondria during depolarization, thereby dampening toxic cytosolic Ca2+ spikes and preventing cell death [1].
SynonymsITH12575, ITH 12575
Chemical Properties
Molecular Weight331.86
FormulaC18H18ClNOS
Cas No.1802013-08-6
SmilesO=C1NC2=CC=C(Cl)C=C2C(SC1)C=3C=CC=CC3C(C)C
Relative Density.1.219 g/cm3 (Predicted)
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (120.53 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0133 mL15.0666 mL30.1332 mL150.6659 mL
5 mM0.6027 mL3.0133 mL6.0266 mL30.1332 mL
10 mM0.3013 mL1.5067 mL3.0133 mL15.0666 mL
20 mM0.1507 mL0.7533 mL1.5067 mL7.5333 mL
50 mM0.0603 mL0.3013 mL0.6027 mL3.0133 mL
100 mM0.0301 mL0.1507 mL0.3013 mL1.5067 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

ITH-12575
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