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8-Hydroxyquinoline-2-carboxaldehyde

Name: 8-Hydroxyquinoline-2-carboxaldehyde
Brand: TargetMol
SKU: T2290
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2290Cas No. 14510-06-6

8-Hydroxyquinoline-2-carboxaldehyde serves as a pharmaceutical intermediate.

8-Hydroxyquinoline-2-carboxaldehyde

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Purity: 97.49%

Catalog No. T2290Cas No. 14510-06-6

8-Hydroxyquinoline-2-carboxaldehyde serves as a pharmaceutical intermediate.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.49%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

8-Hydroxyquinoline-2-carboxaldehyde AI Summary

8-Hydroxyquinoline-2-carboxaldehyde exhibits a range of bioactivities including up-regulation of CLGN gene expression and down-regulation of CCL5 gene expression in human KYSE-150 cells. It displays cytotoxic effects on various human cell lines such as K562, T47D, Hep3B, SKHEP1, Saos2, Hs578T, MDA-MB-231, A549, NE3, and HaCaT with varying IC50 values, including specific IC50 values of 16.06 µg/mL and 19.15 µg/mL for NE3 and HaCaT cells, respectively. The compound shows a ratio of IC50 values for T47D cells compared to CDDP and demonstrates higher concentration activity against K562 and T47D cells. Additionally, 8-Hydroxyquinoline-2-carboxaldehyde acts as an inhibitor of recombinant human IDO1, inhibiting 16.0% of activity in an assay using L-tryptophan as the substrate. It also has antibacterial properties, showing a 7.5 mm inhibition zone against Staphylococcus aureus at 50 µg/mL and an MIC of 50.0 µg/mL but exhibits minimal activity against Escherichia coli..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

8-Hydroxyquinoline-2-carboxaldehyde serves as a pharmaceutical intermediate.

Chemical Properties

Molecular Weight	173.17
Formula	C₁₀H₇NO₂
Cas No.	14510-06-6
Smiles	Oc1cccc2ccc(C=O)nc12
Relative Density.	1.364 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (288.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7747 mL	28.8734 mL	57.7467 mL	288.7336 mL
5 mM	1.1549 mL	5.7747 mL	11.5493 mL	57.7467 mL
10 mM	0.5775 mL	2.8873 mL	5.7747 mL	28.8734 mL
20 mM	0.2887 mL	1.4437 mL	2.8873 mL	14.4367 mL
50 mM	0.1155 mL	0.5775 mL	1.1549 mL	5.7747 mL
100 mM	0.0577 mL	0.2887 mL	0.5775 mL	2.8873 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

8-Hydroxyquinoline-2-carboxaldehyde8Hydroxyquinoline2carboxaldehyde8 Hydroxyquinoline 2 carboxaldehyde

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