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L-798106
🥰Excellent
Catalog No. T15689Cas No. 244101-02-8
Alias L 798106, GW-671021, GW671021, CM-9, CM9
L-798106 (CM9) is a selective and potent prostaglandin-like EP3 receptor antagonist that inhibits EP4, EP1, and EP2 receptors, suppresses levels of pro-inflammatory cytokines in atherosclerosis, and attenuates PGE2-induced cough.
L-798106
🥰Excellent
Purity: 98.97%
Catalog No. T15689Alias L 798106, GW-671021, GW671021, CM-9, CM9Cas No. 244101-02-8
L-798106 (CM9) is a selective and potent prostaglandin-like EP3 receptor antagonist that inhibits EP4, EP1, and EP2 receptors, suppresses levels of pro-inflammatory cytokines in atherosclerosis, and attenuates PGE2-induced cough.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $41 | In Stock | In Stock | |
| 5 mg | $106 | In Stock | In Stock | |
| 10 mg | $168 | In Stock | In Stock | |
| 25 mg | $347 | In Stock | In Stock | |
| 50 mg | $558 | In Stock | In Stock | |
| 100 mg | $893 | In Stock | In Stock | |
| 200 mg | $1,180 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.97%
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Product Introduction
Bioactivity
Chemical Properties
| Description | L-798106 (CM9) is a selective and potent prostaglandin-like EP3 receptor antagonist that inhibits EP4, EP1, and EP2 receptors, suppresses levels of pro-inflammatory cytokines in atherosclerosis, and attenuates PGE2-induced cough. |
| Targets&IC50 | EP3 receptor:0.3 nM(Ki), EP3 receptor: 0.3 nM(ki), EP4 receptor:916 nM(ki), EP4 receptor:916 nM(Ki), EP1/2 receptor:> 5000 nM(ki), EP1/2 receptor:> 5000 nM(Ki) |
| In vitro | In the guinea-pig vas deferens, L-798106 (200 nM) showed an apparent pA2 of 7.48±0.25[2]. |
| In vivo | In male db/db mice, L-798106 (50 and 100 μg/kg; oral gavage; once daily; 8 weeks) suppressed the increased fasting blood glucose levels and inhibited the increased proinflammatory gene expressions in adipocytes isolated from epididymal adipose tissue of db/db mice[3]. |
| Synonyms | L 798106, GW-671021, GW671021, CM-9, CM9 |
| Molecular Weight | 536.44 |
| Formula | C27H22BrNO4S |
| Cas No. | 244101-02-8 |
| Smiles | COc1ccc(Br)cc1S(=O)(=O)NC(=O)\C=C\c1ccccc1Cc1ccc2ccccc2c1 |
| Relative Density. | 1.425 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (9.32 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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