Shopping Cart
Remove All
Your shopping cart is currently empty
L-798106 (Synonyms: L 798106, GW-671021, GW671021, CM-9, CM9)
Catalog No. T15689 Copy Product Info
Purity: 98.97%
🥰Excellent
L-798106 (CM9) is a selective and potent prostaglandin-like EP3 receptor antagonist that inhibits EP4, EP1, and EP2 receptors, suppresses levels of pro-inflammatory cytokines in atherosclerosis, and attenuates PGE2-induced cough.
L-798106
Copy Product Info🥰Excellent
Catalog No. T15689
Synonyms L 798106, GW-671021, GW671021, CM-9, CM9
L-798106 (CM9) is a selective and potent prostaglandin-like EP3 receptor antagonist that inhibits EP4, EP1, and EP2 receptors, suppresses levels of pro-inflammatory cytokines in atherosclerosis, and attenuates PGE2-induced cough.
Cas No. 244101-02-8
Customer service consultation
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $41 | In Stock | In Stock | |
| 5 mg | $106 | In Stock | In Stock | |
| 10 mg | $168 | In Stock | In Stock | |
| 25 mg | $347 | In Stock | In Stock | |
| 50 mg | $558 | In Stock | In Stock | |
| 100 mg | $893 | In Stock | In Stock | |
| 200 mg | $1,180 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
Select Batch
Purity:98.97%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-798106 (CM9) is a selective and potent prostaglandin-like EP3 receptor antagonist that inhibits EP4, EP1, and EP2 receptors, suppresses levels of pro-inflammatory cytokines in atherosclerosis, and attenuates PGE2-induced cough. |
| Targets&IC50 | EP4 receptor:916 nM(ki), EP3 receptor:0.3 nM(Ki), EP3 receptor: 0.3 nM(ki), EP4 receptor:916 nM(Ki), EP1/2 receptor:> 5000 nM(ki), EP1/2 receptor:> 5000 nM(Ki) |
| In vitro | In the guinea-pig vas deferens, L-798106 (200 nM) showed an apparent pA2 of 7.48±0.25[2]. |
| In vivo | In male db/db mice, L-798106 (50 and 100 μg/kg; oral gavage; once daily; 8 weeks) suppressed the increased fasting blood glucose levels and inhibited the increased proinflammatory gene expressions in adipocytes isolated from epididymal adipose tissue of db/db mice[3]. |
| Synonyms | L 798106, GW-671021, GW671021, CM-9, CM9 |
| Molecular Weight | 536.44 |
| Formula | C27H22BrNO4S |
| Cas No. | 244101-02-8 |
| Smiles | COc1ccc(Br)cc1S(=O)(=O)NC(=O)\C=C\c1ccccc1Cc1ccc2ccccc2c1 |
| Relative Density. | 1.425 g/cm3 (Predicted) |
| Storage | Keep away from moisture | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (9.32 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy L-798106 | purchase L-798106 | L-798106 cost | order L-798106 | L-798106 chemical structure | L-798106 in vivo | L-798106 in vitro | L-798106 formula | L-798106 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.