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NH2-PEG2-C6-Cl

Name: NH2-PEG2-C6-Cl
Brand: TargetMol
SKU: T40858
Rating: 4.5 (1 reviews)

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Catalog No. T40858Cas No. 744203-60-9

Alias NH2-PEG2-C6-Cl

NH2-PEG2-C6-Cl is a PEG-based linker for PROTACs, facilitating the formation of PROTAC molecules by joining two essential ligands. It enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

NH2-PEG2-C6-Cl

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Catalog No. T40858Alias NH2-PEG2-C6-ClCas No. 744203-60-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	Inquiry	Inquiry
10 mg	$47	Inquiry	Inquiry
25 mg	$77	Inquiry	Inquiry
50 mg	$115	Inquiry	Inquiry
100 mg	$182	Inquiry	Inquiry
200 mg	$271	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	NH2-PEG2-C6-Cl is a PEG-based linker for PROTACs, facilitating the formation of PROTAC molecules by joining two essential ligands. It enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .
Synonyms	NH2-PEG2-C6-Cl

Chemical Properties

Molecular Weight	223.74
Formula	C₁₀H₂₂ClNO₂
Cas No.	744203-60-9
Smiles	C(OCCOCCN)CCCCCCl

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (402.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4695 mL	22.3474 mL	44.6947 mL	223.4737 mL
5 mM	0.8939 mL	4.4695 mL	8.9389 mL	44.6947 mL
10 mM	0.4469 mL	2.2347 mL	4.4695 mL	22.3474 mL
20 mM	0.2235 mL	1.1174 mL	2.2347 mL	11.1737 mL
50 mM	0.0894 mL	0.4469 mL	0.8939 mL	4.4695 mL
100 mM	0.0447 mL	0.2235 mL	0.4469 mL	2.2347 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc