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CPTH2 (hydrochloride) (357649-93-5 free base)

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Catalog No. T22693Cas No. 2108899-91-6
Alias CPTH2 (hydrochloride)

CPTH2 is an inhibitor of the HAT activity of Gcn5.

CPTH2 (hydrochloride) (357649-93-5 free base)
Other Forms of CPTH2 (hydrochloride) (357649-93-5 free base):
CPTH2T8344357649-93-5
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CPTH2 (hydrochloride) (357649-93-5 free base)

Copy Product Info
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Catalog No. T22693Alias CPTH2 (hydrochloride)Cas No. 2108899-91-6
CPTH2 is an inhibitor of the HAT activity of Gcn5.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$35235 days35 days
10 mg$46335 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
CPTH2 is an inhibitor of the HAT activity of Gcn5.
In vitro
In vitro: The previous study identified a novel molecule named CPTH2, which was selected based on its inhibitory effect on the growth of a gcn5Delta strain. This study indicated a specific chemical-genetic interaction between CPTH2 and HAT Gcn5p, suggesting that CPTH2 could inhibit the dependent functional network of Gcn5p. In addition, CPTH2 was found to be able to inhibit an in-vitro HAT reaction, which could be reversed by increasing the concentration of histone H3 [1].
In vivo
In vivo: CPTH2 could decrease the acetylation of bulk histone H3 at the specific H3-AcK14 site [1].
SynonymsCPTH2 (hydrochloride)
Chemical Properties
Molecular Weight328.26
FormulaC14H15Cl2N3S
Cas No.2108899-91-6
SmilesCl.ClC=1C=CC(=CC1)C=2N=C(SC2)NN=C3CCCC3
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 16 mg/mL (48.74 mM), Sonication is recommended.
Ethanol: ≤5 mg/mL, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0464 mL15.2318 mL30.4637 mL152.3183 mL
5 mM0.6093 mL3.0464 mL6.0927 mL30.4637 mL
10 mM0.3046 mL1.5232 mL3.0464 mL15.2318 mL
20 mM0.1523 mL0.7616 mL1.5232 mL7.6159 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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