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CPTH2 (hydrochloride) (357649-93-5 free base)

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Catalog No. T22693Cas No. 2108899-91-6
Alias CPTH2 (hydrochloride)

CPTH2 is an inhibitor of the HAT activity of Gcn5.

CPTH2 (hydrochloride) (357649-93-5 free base)
Other Forms of CPTH2 (hydrochloride) (357649-93-5 free base):
CPTH2T8344357649-93-5
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CPTH2 (hydrochloride) (357649-93-5 free base)

😃Good
Catalog No. T22693Alias CPTH2 (hydrochloride)Cas No. 2108899-91-6
CPTH2 is an inhibitor of the HAT activity of Gcn5.
Pack SizePriceAvailabilityQuantity
5 mg$35235 days
10 mg$46335 days
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Product Introduction

Bioactivity
Description
CPTH2 is an inhibitor of the HAT activity of Gcn5.
In vitro
In vitro: The previous study identified a novel molecule named CPTH2, which was selected based on its inhibitory effect on the growth of a gcn5Delta strain. This study indicated a specific chemical-genetic interaction between CPTH2 and HAT Gcn5p, suggesting that CPTH2 could inhibit the dependent functional network of Gcn5p. In addition, CPTH2 was found to be able to inhibit an in-vitro HAT reaction, which could be reversed by increasing the concentration of histone H3 [1].
In vivo
In vivo: CPTH2 could decrease the acetylation of bulk histone H3 at the specific H3-AcK14 site [1].
SynonymsCPTH2 (hydrochloride)
Chemical Properties
Molecular Weight328.26
FormulaC14H15Cl2N3S
Cas No.2108899-91-6
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 16 mg/mL (48.74 mM), Sonication is recommended.
Ethanol: ≤5 mg/mL, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0464 mL15.2318 mL30.4637 mL152.3183 mL
5 mM0.6093 mL3.0464 mL6.0927 mL30.4637 mL
10 mM0.3046 mL1.5232 mL3.0464 mL15.2318 mL
20 mM0.1523 mL0.7616 mL1.5232 mL7.6159 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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