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Prostaglandin D2 methyl ester

Name: Prostaglandin D2 methyl ester
Brand: TargetMol
SKU: T36545
Rating: 4.5 (1 reviews)

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Catalog No. T36545Cas No. 49852-81-5

Alias Prostaglandin D2 methyl ester

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypotension, and is an inhibitor of platelet aggregation. Prostaglandin D2 methyl ester (PGD2 methyl ester) is a more lipid-soluble, cell-permeable prodrug form of PGD2. It binds to the human and mouse PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.

Prostaglandin D2 methyl ester

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Catalog No. T36545Alias Prostaglandin D2 methyl esterCas No. 49852-81-5

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$156	35 days	35 days
1 mg	$287	35 days	35 days
5 mg	$1,200	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Synonyms

Prostaglandin D2 methyl ester

Chemical Properties

Molecular Weight	366.498
Formula	C₂₁H₃₄O₅
Cas No.	49852-81-5
Smiles	CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(=O)OC)[C@@H](O)CC1=O
Relative Density.	1.103 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (136.43 mM), Sonication is recommended.

PBS (pH 7.2): 1 mg/mL (2.73 mM), Sonication is recommended.

DMF: 50 mg/mL (136.43 mM), Sonication is recommended.

Ethanol: 50 mg/mL (136.43 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.7285 mL	13.6426 mL	27.2853 mL	136.4264 mL

DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.5457 mL	2.7285 mL	5.4571 mL	27.2853 mL
10 mM	0.2729 mL	1.3643 mL	2.7285 mL	13.6426 mL
20 mM	0.1364 mL	0.6821 mL	1.3643 mL	6.8213 mL
50 mM	0.0546 mL	0.2729 mL	0.5457 mL	2.7285 mL
100 mM	0.0273 mL	0.1364 mL	0.2729 mL	1.3643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc