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Prostaglandin D2 methyl ester

Catalog No. T36545 CAS 49852-81-5

Synonyms: Prostaglandin D2 methyl ester

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypotension, and is an inhibitor of platelet aggregation. Prostaglandin D2 methyl ester (PGD2 methyl ester) is a more lipid-soluble, cell-permeable prodrug form of PGD2. It binds to the human and mouse PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.

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Prostaglandin D2 methyl ester Chemical Structure

Prostaglandin D2 methyl ester, CAS 49852-81-5

Pack Size	Availability	Price/USD
500 μg	35 days	$ 108.00
1 mg	35 days	$ 198.00
5 mg	35 days	$ 830.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Prostaglandin D2 methyl ester
Molecular Weight	366.498
Formula	C21H34O5
CAS No.	49852-81-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL

PBS (pH 7.2): 1 mg/mL

DMF: 50 mg/mL

Ethanol: 50 mg/mL

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You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Prostaglandin D2 methyl ester 49852-81-5 Prostaglandin D-2 methyl ester inhibitor inhibit

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