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LY255582
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Catalog No. T27934Cas No. 119193-09-8
Alias LY-255582, LY 255582
LY255582 is a selective centrally active opioid receptor antagonist with high affinity for mu, delta and kappa receptors with Ki of 0.4 nM, 5.2, 2.0 nM, respectively. LY255582 inhibits diet-associated increases in mesolimbic dopamine levels and reduces consumption of food intake. LY255582 is commonly used in obesity research. LY255582 is a potential compound for the study of opioid receptor-mediated cell signaling.
LY255582
😃Good
Catalog No. T27934Alias LY-255582, LY 255582Cas No. 119193-09-8
LY255582 is a selective centrally active opioid receptor antagonist with high affinity for mu, delta and kappa receptors with Ki of 0.4 nM, 5.2, 2.0 nM, respectively. LY255582 inhibits diet-associated increases in mesolimbic dopamine levels and reduces consumption of food intake. LY255582 is commonly used in obesity research. LY255582 is a potential compound for the study of opioid receptor-mediated cell signaling.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $490 | 3-6 months | |
| 50 mg | $1,950 | 3-6 months | |
| 100 mg | $3,800 | 3-6 months |
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Product Introduction
Bioactivity
Chemical Properties
| Description | LY255582 is a selective centrally active opioid receptor antagonist with high affinity for mu, delta and kappa receptors with Ki of 0.4 nM, 5.2, 2.0 nM, respectively. LY255582 inhibits diet-associated increases in mesolimbic dopamine levels and reduces consumption of food intake. LY255582 is commonly used in obesity research. LY255582 is a potential compound for the study of opioid receptor-mediated cell signaling. |
| Targets&IC50 | μ opioid:0.4 nM (Ki ), Delta:5.2 nM (Ki ), κ opioid:2 nM (Ki ) |
| In vitro | LY255582 (40 μM, 24-72 h) biologically inhibits the viability of Huh7 and MHCC-97H cells.[1] |
| In vivo | LY255582 (100 μg, i.c.v.) reduces food intake in rats [2].
LY255582 (15 mg/kg/d, s.c., once daily) decreases food intake and body weight gain in obese Zucker rats [3]. |
| Synonyms | LY-255582, LY 255582 |
| Molecular Weight | 345.52 |
| Formula | C22H35NO2 |
| Cas No. | 119193-09-8 |
| Smiles | C[C@H]1CN(CC[C@H](O)C2CCCCC2)CC[C@@]1(C)c1cccc(O)c1 |
| Relative Density. | 1.045 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 13.5 mg/mL (39.07 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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