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LY255582

Name: LY255582
Brand: TargetMol
SKU: T27934
Rating: 4.5 (1 reviews)

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Catalog No. T27934Cas No. 119193-09-8

Alias LY-255582, LY 255582

LY255582 is a selective centrally active opioid receptor antagonist with high affinity for mu, delta and kappa receptors with Ki of 0.4 nM, 5.2, 2.0 nM, respectively. LY255582 inhibits diet-associated increases in mesolimbic dopamine levels and reduces consumption of food intake. LY255582 is commonly used in obesity research. LY255582 is a potential compound for the study of opioid receptor-mediated cell signaling.

LY255582

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Catalog No. T27934Alias LY-255582, LY 255582Cas No. 119193-09-8

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$490	3-6 months	3-6 months
50 mg	$1,950	3-6 months	3-6 months
100 mg	$3,800	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	LY255582 is a selective centrally active opioid receptor antagonist with high affinity for mu, delta and kappa receptors with Ki of 0.4 nM, 5.2, 2.0 nM, respectively. LY255582 inhibits diet-associated increases in mesolimbic dopamine levels and reduces consumption of food intake. LY255582 is commonly used in obesity research. LY255582 is a potential compound for the study of opioid receptor-mediated cell signaling.
Targets&IC50	Delta:5.2 nM (Ki ), κ opioid:2 nM (Ki ), μ opioid:0.4 nM (Ki )
In vitro	LY255582 (40 μM, 24-72 h) biologically inhibits the viability of Huh7 and MHCC-97H cells.[1]
In vivo	LY255582 (100 μg, i.c.v.) reduces food intake in rats [2]. LY255582 (15 mg/kg/d, s.c., once daily) decreases food intake and body weight gain in obese Zucker rats [3].
Synonyms	LY-255582, LY 255582

Chemical Properties

Molecular Weight	345.52
Formula	C₂₂H₃₅NO₂
Cas No.	119193-09-8
Smiles	C[C@H]1CN(CC[C@H](O)C2CCCCC2)CC[C@@]1(C)c1cccc(O)c1
Relative Density.	1.045 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 13.5 mg/mL (39.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8942 mL	14.4709 mL	28.9419 mL	144.7094 mL
5 mM	0.5788 mL	2.8942 mL	5.7884 mL	28.9419 mL
10 mM	0.2894 mL	1.4471 mL	2.8942 mL	14.4709 mL
20 mM	0.1447 mL	0.7235 mL	1.4471 mL	7.2355 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc