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AhR agonist 2

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Catalog No. T61244

AhR agonist 2 is a triazolopyridine derivative and novel aryl hydrocarbon receptor (AhR) agonist with the advantages of being orally bioavailable and highly potent (EC50=0.03 nM), inducing rapid nuclear enrichment of the AhR and facilitating skin barrier repair for the treatment of psoriasis.

AhR agonist 2

AhR agonist 2

😃Good
Catalog No. T61244
AhR agonist 2 is a triazolopyridine derivative and novel aryl hydrocarbon receptor (AhR) agonist with the advantages of being orally bioavailable and highly potent (EC50=0.03 nM), inducing rapid nuclear enrichment of the AhR and facilitating skin barrier repair for the treatment of psoriasis.
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2 mg$585 days5 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
AhR agonist 2 is a triazolopyridine derivative and novel aryl hydrocarbon receptor (AhR) agonist with the advantages of being orally bioavailable and highly potent (EC50=0.03 nM), inducing rapid nuclear enrichment of the AhR and facilitating skin barrier repair for the treatment of psoriasis.
Chemical Properties
Molecular Weight353.01
FormulaC12H7Br2N3
SmilesBrC=1C=CC(=CC1)C=2N=C3C=CC(Br)=CN3N2
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 16 mg/mL (45.32 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8328 mL14.1639 mL28.3278 mL141.6390 mL
5 mM0.5666 mL2.8328 mL5.6656 mL28.3278 mL
10 mM0.2833 mL1.4164 mL2.8328 mL14.1639 mL
20 mM0.1416 mL0.7082 mL1.4164 mL7.0820 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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