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Gonadorelin Acetate (33515-09-2 free base)

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Catalog No. T5015Cas No. 71447-49-9
Alias Luteinizing Hormone Releasing Hormone (LH-RH), human, Luteinizing Hormone Releasing Hormone (LH-RH), Gonadorelin Acetate

Gonadorelin Acetate (33515-09-2 free base) (Luteinizing Hormone Releasing Hormone (LH-RH)) is hypothalamic neuropeptide which plays a key role in the control of reproductive functions.

Gonadorelin Acetate (33515-09-2 free base)
Other Forms of Gonadorelin Acetate (33515-09-2 free base):

Gonadorelin Acetate (33515-09-2 free base)

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Purity: 99.46%
Catalog No. T5015Alias Luteinizing Hormone Releasing Hormone (LH-RH), human, Luteinizing Hormone Releasing Hormone (LH-RH), Gonadorelin AcetateCas No. 71447-49-9
Gonadorelin Acetate (33515-09-2 free base) (Luteinizing Hormone Releasing Hormone (LH-RH)) is hypothalamic neuropeptide which plays a key role in the control of reproductive functions.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$34In StockIn Stock
5 mg$72In StockIn Stock
10 mg$98In StockIn Stock
25 mg$185In StockIn Stock
50 mg$279In StockIn Stock
100 mg$417In StockIn Stock
500 mg$988-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.46%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Gonadorelin Acetate (33515-09-2 free base) (Luteinizing Hormone Releasing Hormone (LH-RH)) is hypothalamic neuropeptide which plays a key role in the control of reproductive functions.
In vitro
Luteinizing Hormone Releasing Hormone (LH-RH), also called gonadotropin-releasing hormone (GnRH), is the primary link between the brain, the pituitary and gonadal function, and has a key role in vertebrate reproduction. The endocrine actions of Luteinizing Hormone Releasing Hormone (LH-RH) and its analogs are mediated by high-affinity membrane receptors for LHRH on pituitary gonadotrophs. LHRH is expressed,together with its receptors,in hormonerelated tumors such as prostate cancer,to act as a local autocrine/paracrine growth inhibitory factor. In prostate cancer cells,the LHRH receptor is coupled to the Gi-cAMP pathway to inhibit cell proliferation.
In vivo
Luteinizing Hormone Releasing Hormone treatment advances the timing of vaginal opening by 5 days, which is used as an initial indicator for the time of puberty.
Animal Research
Rat:Immature female Sprague-Dawley rats receive either 50 ng Luteinizing Hormone Releasing Hormone (LH-RH)/kg BW or 20 mg NMA/kg BW in a 10% dextrose, 0.9% NaCl solution, while controls receive only vehicle. After completion of the treatment, rats are examined daily for vaginal opening.
SynonymsLuteinizing Hormone Releasing Hormone (LH-RH), human, Luteinizing Hormone Releasing Hormone (LH-RH), Gonadorelin Acetate
Chemical Properties
Molecular Weight1302.39
FormulaC59H83N17O17
Cas No.71447-49-9
SmilesCC(O)=O.CC(O)=O.CC(C)CC(NC(=O)CNC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(N)=O
Relative Density.no data available
SequenceH-Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Sequence ShortXHWSYGLRPG
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 10 mM, Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.7678 mL3.8391 mL7.6782 mL38.3910 mL
5 mM0.1536 mL0.7678 mL1.5356 mL7.6782 mL
10 mM0.0768 mL0.3839 mL0.7678 mL3.8391 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Luteinizing Hormone Releasing HormoneLH-RHGonadorelin Acetate (33515092 free base)Gonadorelin Acetate (33515 09 2 free base)5-α reductase33515-09-2 free base33515-09-2
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