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TREM2 agonist-2

Name: TREM2 agonist-2
Brand: TargetMol
SKU: T62750
Price: 283 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62750Cas No. 2738485-98-6

TREM2 agonist-2 (I-192) is an orally active and potent agonist of myeloid triggered receptor 2 (TREM2) for neurodegenerative disease research.

TREM2 agonist-2

🥰Excellent

Purity: 99.71%

Catalog No. T62750Cas No. 2738485-98-6

TREM2 agonist-2 (I-192) is an orally active and potent agonist of myeloid triggered receptor 2 (TREM2) for neurodegenerative disease research.

Pack Size	Price	Availability
1 mg	$283	In Stock
5 mg	$698	In Stock
10 mg	$1,160	In Stock
25 mg	$2,130	In Stock
50 mg	$2,780	In Stock
100 mg	$3,520	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.71%

ee:100%

Resource Download

COA CSFC FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	TREM2 agonist-2 (I-192) is an orally active and potent agonist of myeloid triggered receptor 2 (TREM2) for neurodegenerative disease research.
Targets&IC50	hTREM2 (HEK293 cells):< 0.05 μM (EC50)
In vitro	Treatment with TREM2 agonist-2 (0-100μM; 16 hours) activated hTREM2 in HEK293 cells, with an EC50 value less than 0.05μM for cell viability assay[1].
In vivo	The results indicate that TREM2 agonist-2 (50 mg/kg; twice daily; oral gavage for one day) can bind to the TREM2 target, which can interact with microglial cells[1].

Chemical Properties

Molecular Weight	451.92
Formula	C₂₄H₂₃ClFN₅O
Cas No.	2738485-98-6
Smiles	CC1=NC=2C(=NC(=CC2N=C1C)[C@@H]3C[C@@H](OCC3)C4=CN(C)N=C4)C5=C(F)C=C(Cl)C=C5
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 257.5 mg/mL (569.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2128 mL	11.0639 mL	22.1278 mL	110.6391 mL
5 mM	0.4426 mL	2.2128 mL	4.4256 mL	22.1278 mL
10 mM	0.2213 mL	1.1064 mL	2.2128 mL	11.0639 mL
20 mM	0.1106 mL	0.5532 mL	1.1064 mL	5.5320 mL
50 mM	0.0443 mL	0.2213 mL	0.4426 mL	2.2128 mL
100 mM	0.0221 mL	0.1106 mL	0.2213 mL	1.1064 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc