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Seganserin

Name: Seganserin
Brand: TargetMol
SKU: T68141
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T68141Cas No. 87729-89-3

Seganserin, a non-selective 5-hydroxytryptamine 2-HT receptor antagonist, reversed the inhibitory effects of fluoxetine and quipazine on luteinizing hormone-induced hyperphagia, depression and nociception, and reversed the antidepressant and analgesic effects induced by fluoxetine and quipazine.

Seganserin

🥰Excellent

Purity: 99.22%

Catalog No. T68141Cas No. 87729-89-3

Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$430	In Stock
10 mg	$636	In Stock
25 mg	$987	In Stock
50 mg	$1,360	In Stock
100 mg	$1,830	In Stock
500 mg	$3,680	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.22%

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COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	Seganserin, a non-selective 5-hydroxytryptamine 2-HT receptor antagonist, reversed the inhibitory effects of fluoxetine and quipazine on luteinizing hormone-induced hyperphagia, depression and nociception, and reversed the antidepressant and analgesic effects induced by fluoxetine and quipazine.
In vivo	Seganserin (2 mg/kg, i.p.; mice), a 5-HT(2) receptor antagonist pretreatment significantly reversed fluoxetine and quipazine-induced antidepressant and analgesic effects.[2] Seganserin (2 mg/kg, i.p.; mice), significantly reversed the suppressive effect of fluoxetine and quipazine on progesterone-induced hyperphagia, depression, and algesia in the hot-plate test.[2]

Chemical Properties

Molecular Weight	471.54
Formula	C₂₉H₂₇F₂N₃O
Cas No.	87729-89-3
Smiles	C(=C1CCN(CCC=2C(=O)N3C(=NC2C)C=CC=C3)CC1)(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (116.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1207 mL	10.6036 mL	21.2071 mL	106.0355 mL
5 mM	0.4241 mL	2.1207 mL	4.2414 mL	21.2071 mL
10 mM	0.2121 mL	1.0604 mL	2.1207 mL	10.6036 mL
20 mM	0.1060 mL	0.5302 mL	1.0604 mL	5.3018 mL
50 mM	0.0424 mL	0.2121 mL	0.4241 mL	2.1207 mL
100 mM	0.0212 mL	0.1060 mL	0.2121 mL	1.0604 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc