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Indinavir (Alias: MK639 free base)

Name: Indinavir
Brand: TargetMol
SKU: T5863L
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Indinavir is an orally administered, specific HIV protease inhibitor commonly used in combination therapy as part of highly active antiretroviral therapy (HAART) for HIV/AIDS. Indinavir also inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.

Indinavir

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Catalog No. T5863L

Alias MK639 free base

Cas No. 150378-17-9

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$67	-	In Stock
5 mg	$162	Inquiry	Inquiry

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Indinavir is an orally administered, specific HIV protease inhibitor commonly used in combination therapy as part of highly active antiretroviral therapy (HAART) for HIV/AIDS. Indinavir also inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.
In vitro	Method: Peripheral blood mononuclear cells (PBMCs) from healthy and HIV-infected individuals were pretreated with Indinavir at concentrations ranging from 0 to 50 μM for 18 hours, followed by stimulation with anti-CD3 antibody for an additional 48 hours. Result: Indinavir inhibited anti-CD3-induced cell cycle progression in a dose-dependent manner and reduced lymphoproliferative responses in a dose-dependent fashion. [1]
In vivo	Method: Huh7 and SK-HEP-1 hepatocarcinoma cells were subcutaneously implanted into nude mice. After tumor establishment, Indinavir was administered by oral gavage at a dose of 70 mg/kg once daily for 3 weeks. Result: Compared with the control group, Indinavir delayed the growth of subcutaneously implanted hepatocarcinoma xenografts in nude mice.[2]
Synonyms	MK639 free base

Chemical Properties

Molecular Weight	613.79
Formula	C₃₆H₄₇N₅O₄
Cas No.	150378-17-9
Smiles	N(C([C@H](CC1=CC=CC=C1)C[C@@H](CN2[C@H](C(NC(C)(C)C)=O)CN(CC=3C=CC=NC3)CC2)O)=O)[C@H]4C=5C(C[C@H]4O)=CC=CC5
Relative Density.	1.25 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (130.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6292 mL	8.1461 mL	16.2922 mL	81.4611 mL
5 mM	0.3258 mL	1.6292 mL	3.2584 mL	16.2922 mL
10 mM	0.1629 mL	0.8146 mL	1.6292 mL	8.1461 mL
20 mM	0.0815 mL	0.4073 mL	0.8146 mL	4.0731 mL
50 mM	0.0326 mL	0.1629 mL	0.3258 mL	1.6292 mL
100 mM	0.0163 mL	0.0815 mL	0.1629 mL	0.8146 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc