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Indinavir
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Catalog No. T5863LCas No. 150378-17-9
Alias MK639 free base
Indinavir is an orally administered, specific HIV protease inhibitor commonly used in combination therapy as part of highly active antiretroviral therapy (HAART) for HIV/AIDS. Indinavir also inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.
Indinavir
Copy Product Info😃Good
Catalog No. T5863LAlias MK639 free baseCas No. 150378-17-9
Indinavir is an orally administered, specific HIV protease inhibitor commonly used in combination therapy as part of highly active antiretroviral therapy (HAART) for HIV/AIDS. Indinavir also inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $67 | - | In Stock | |
| 5 mg | $162 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Color:White
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| Description | Indinavir is an orally administered, specific HIV protease inhibitor commonly used in combination therapy as part of highly active antiretroviral therapy (HAART) for HIV/AIDS. Indinavir also inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro. |
| In vitro | Method: Peripheral blood mononuclear cells (PBMCs) from healthy and HIV-infected individuals were pretreated with Indinavir at concentrations ranging from 0 to 50 μM for 18 hours, followed by stimulation with anti-CD3 antibody for an additional 48 hours. Result: Indinavir inhibited anti-CD3-induced cell cycle progression in a dose-dependent manner and reduced lymphoproliferative responses in a dose-dependent fashion. [1] |
| In vivo | Method: Huh7 and SK-HEP-1 hepatocarcinoma cells were subcutaneously implanted into nude mice. After tumor establishment, Indinavir was administered by oral gavage at a dose of 70 mg/kg once daily for 3 weeks. Result: Compared with the control group, Indinavir delayed the growth of subcutaneously implanted hepatocarcinoma xenografts in nude mice.[2] |
| Synonyms | MK639 free base |
| Molecular Weight | 613.79 |
| Formula | C36H47N5O4 |
| Cas No. | 150378-17-9 |
| Smiles | N(C([C@H](CC1=CC=CC=C1)C[C@@H](CN2[C@H](C(NC(C)(C)C)=O)CN(CC=3C=CC=NC3)CC2)O)=O)[C@H]4C=5C(C[C@H]4O)=CC=CC5 |
| Relative Density. | 1.25 g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (130.34 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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