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Indinavir
🥰Excellent
Catalog No. T5863LCas No. 150378-17-9
Alias MK639 free base
Indinavir is an orally administered, specific HIV protease inhibitor commonly used in combination therapy as part of highly active antiretroviral therapy (HAART) for HIV/AIDS. Indinavir also inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.
Indinavir
🥰Excellent
Catalog No. T5863LAlias MK639 free baseCas No. 150378-17-9
Indinavir is an orally administered, specific HIV protease inhibitor commonly used in combination therapy as part of highly active antiretroviral therapy (HAART) for HIV/AIDS. Indinavir also inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $67 | In Stock | |
| 5 mg | $162 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Indinavir is an orally administered, specific HIV protease inhibitor commonly used in combination therapy as part of highly active antiretroviral therapy (HAART) for HIV/AIDS. Indinavir also inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro. |
| In vitro | Method: Peripheral blood mononuclear cells (PBMCs) from healthy and HIV-infected individuals were pretreated with Indinavir at concentrations ranging from 0 to 50 μM for 18 hours, followed by stimulation with anti-CD3 antibody for an additional 48 hours. Result: Indinavir inhibited anti-CD3-induced cell cycle progression in a dose-dependent manner and reduced lymphoproliferative responses in a dose-dependent fashion. [1] |
| In vivo | Method: Huh7 and SK-HEP-1 hepatocarcinoma cells were subcutaneously implanted into nude mice. After tumor establishment, Indinavir was administered by oral gavage at a dose of 70 mg/kg once daily for 3 weeks. Result: Compared with the control group, Indinavir delayed the growth of subcutaneously implanted hepatocarcinoma xenografts in nude mice.[2] |
| Synonyms | MK639 free base |
| Molecular Weight | 613.79 |
| Formula | C36H47N5O4 |
| Cas No. | 150378-17-9 |
| Smiles | N(C([C@H](CC1=CC=CC=C1)C[C@@H](CN2[C@H](C(NC(C)(C)C)=O)CN(CC=3C=CC=NC3)CC2)O)=O)[C@H]4C=5C(C[C@H]4O)=CC=CC5 |
| Relative Density. | 1.25 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (130.34 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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