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NU 9056

Name: NU 9056
Brand: TargetMol
SKU: T23095
Price: 247 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23095Cas No. 1450644-28-6

Alias NU9056

NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.

NU 9056

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Purity: 97.11%

Catalog No. T23095Alias NU9056Cas No. 1450644-28-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	-	In Stock
2 mg	$98	-	In Stock
5 mg	$158	-	In Stock
10 mg	$247	-	In Stock
25 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$176	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.11%

Color:Transparent to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.
In vitro	NU 9056 shows IC50s of 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively. In LNCaP cells, NU 9056 (17 µM, 24 µM, 36 µM) activates both caspase 3 and caspase 9 in a time- and concentration-dependent manner thereby inducing apoptosis. NU 9056 (2.5 µM, 5 µM, 10 µM, 20 µM, 40 µM) decreases the levels of acetylated histone H4K16, H3K14 and H4K8. NU 9056 causes a reduction of androgen receptor, prostate specific antigen, p53 and p21 protein levels[2].
In vivo	In mice, NU 9056 (2 μg/g) inhibits Tip60 and reduces H2A.Z binding at the the +1 nucleosome of Arc and Syp and the -1 nucleosome of Arc. NU 9056 increases the acetylation at the +1 nucleosome of Gria4 and the -1 nucleosome of Fos, Tacstd2, and Gria4[1].
Synonyms	NU9056

Chemical Properties

Molecular Weight	232.37
Formula	C₆H₄N₂S₄
Cas No.	1450644-28-6
Smiles	S(Sc1ccns1)c1ccns1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (484.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (14.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3035 mL	21.5174 mL	43.0348 mL	215.1741 mL
5 mM	0.8607 mL	4.3035 mL	8.6070 mL	43.0348 mL
10 mM	0.4303 mL	2.1517 mL	4.3035 mL	21.5174 mL
20 mM	0.2152 mL	1.0759 mL	2.1517 mL	10.7587 mL
50 mM	0.0861 mL	0.4303 mL	0.8607 mL	4.3035 mL
100 mM	0.0430 mL	0.2152 mL	0.4303 mL	2.1517 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc