Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Macrophage-activating lipopeptide 2

Name: Macrophage-activating lipopeptide 2
Brand: TargetMol
SKU: TP2791
Rating: 4.5 (1 reviews)

😃Good

Catalog No. TP2791Cas No. 250718-44-6

Alias MALP-2

Macrophage-activating lipopeptide 2 (MALP-2) is a lipopeptide that acts as an agonist for Toll-like receptors TLR-2 and TLR-6. It enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, thereby improving vasodilation. Additionally, MALP-2 increases the adhesion of leukocytes to the endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).

Macrophage-activating lipopeptide 2

😃Good

Catalog No. TP2791Alias MALP-2Cas No. 250718-44-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Macrophage-activating lipopeptide 2 (MALP-2) is a lipopeptide that acts as an agonist for Toll-like receptors TLR-2 and TLR-6. It enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, thereby improving vasodilation. Additionally, MALP-2 increases the adhesion of leukocytes to the endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).
In vitro	Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) enhances the expression of primary endothelial adhesion molecules and leukocyte integrin receptors, thereby improving leukocyte endothelial adhesion. Additionally, Macrophage-activating lipopeptide 2 (1 µg/mL, 2 h) promotes the phosphorylation of Protein Kinase B and eNOS in endothelial MyEnd cells, facilitating the release of nitric oxide (NO).
In vivo	Macrophage-activating lipopeptide 2 (1 µg dissolved in 125 µL PBS; administered daily; for 10 days; via intravenous injection) enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe knockout mice subjected to experimental femoral artery ligation (FAL).
Synonyms	MALP-2

Chemical Properties

Molecular Weight	2135.56
Formula	C₉₉H₁₆₇N₁₉O₃₀S
Cas No.	250718-44-6
Smiles	[C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CCC(O)=O)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CSC[C@@H](COC(CCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCC)=O)N)=O)=O)CC(N)=O)=O)CC(N)=O)=O)CC(O)=O)=O)CCC(O)=O)=O)CO)=O)CC(N)=O)=O)[C@H](CC)C)=O)CO)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: buy Macrophage-activating lipopeptide 2 | purchase Macrophage-activating lipopeptide 2 | Macrophage-activating lipopeptide 2 cost | order Macrophage-activating lipopeptide 2 | Macrophage-activating lipopeptide 2 chemical structure | Macrophage-activating lipopeptide 2 in vivo | Macrophage-activating lipopeptide 2 in vitro | Macrophage-activating lipopeptide 2 formula | Macrophage-activating lipopeptide 2 molecular weight