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(S)-Gossypol acetic acid

Name: (S)-Gossypol acetic acid
Brand: TargetMol
SKU: T13980
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13980Cas No. 1189561-66-7

Alias (S)-(+)-Gossypol acetic acid

(S)-Gossypol acetic acid ((S)-(+)-Gossypol acetic acid) is a conformational isomer of Gossypol that acts as a BH3 mimic capable of binding Bcl-xL and Bcl-2 proteins, with the potential to induce apoptosis and inhibit cell growth.

(S)-Gossypol acetic acid

🥰Excellent

Purity: 98.69%

Catalog No. T13980Alias (S)-(+)-Gossypol acetic acidCas No. 1189561-66-7

Pack Size	Price	Availability	Quantity
2 mg	$45	In Stock
1 mL x 10 mM (in DMSO)	$131	In Stock

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Purity:98.69%

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COA

Product Introduction

Bioactivity

Description	(S)-Gossypol acetic acid ((S)-(+)-Gossypol acetic acid) is a conformational isomer of Gossypol that acts as a BH3 mimic capable of binding Bcl-xL and Bcl-2 proteins, with the potential to induce apoptosis and inhibit cell growth.
In vitro	(S)-Gossypol acetic acid inhibits proliferation and induces apoptosis in human nasopharyngeal carcinoma CNE-2 cells in a dose-dependent manner (2.5-20 μM, 24 h). (S)-Gossypol acetic acid decreases mitochondrial membrane potential, upregulates Bax, downregulates Bcl-2, and activates caspase-3[1].
In vivo	In BALB/c nude mice bearing CNE-2 xenograft tumors, intraperitoneal administration of (S)-Gossypol acetic acid at 20 mg/kg/day for 21 days significantly inhibited tumor growth (~60% reduction in volume) without notable weight loss or systemic toxicity[1].
Alias	(S)-(+)-Gossypol acetic acid

Chemical Properties

Molecular Weight	578.61
Formula	C₃₂H₃₄O₁₀
Cas No.	1189561-66-7
Smiles	O=CC1=C(O)C(O)=C(C2=CC(=C(C(O)=C12)C3=C(O)C4=C(C=O)C(O)=C(O)C(=C4C=C3C)C(C)C)C)C(C)C.O=C(O)C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (69.13 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7283 mL	8.6414 mL	17.2828 mL	86.4140 mL
5 mM	0.3457 mL	1.7283 mL	3.4566 mL	17.2828 mL
10 mM	0.1728 mL	0.8641 mL	1.7283 mL	8.6414 mL
20 mM	0.0864 mL	0.4321 mL	0.8641 mL	4.3207 mL
50 mM	0.0346 mL	0.1728 mL	0.3457 mL	1.7283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc