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(S)-Gossypol acetic acid

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Catalog No. T13980Cas No. 1189561-66-7
Alias (S)-(+)-Gossypol acetic acid

(S)-Gossypol acetic acid ((S)-(+)-Gossypol acetic acid) is a conformational isomer of Gossypol that acts as a BH3 mimic capable of binding Bcl-xL and Bcl-2 proteins, with the potential to induce apoptosis and inhibit cell growth.

(S)-Gossypol acetic acid
Other Forms of (S)-Gossypol acetic acid:

(S)-Gossypol acetic acid

🥰Excellent
Purity: 98.69%
Catalog No. T13980Alias (S)-(+)-Gossypol acetic acidCas No. 1189561-66-7
(S)-Gossypol acetic acid ((S)-(+)-Gossypol acetic acid) is a conformational isomer of Gossypol that acts as a BH3 mimic capable of binding Bcl-xL and Bcl-2 proteins, with the potential to induce apoptosis and inhibit cell growth.
Pack SizePriceAvailabilityQuantity
2 mg$45In Stock
1 mL x 10 mM (in DMSO)$131In Stock
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Purity:98.69%
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Product Introduction

Bioactivity
Description
(S)-Gossypol acetic acid ((S)-(+)-Gossypol acetic acid) is a conformational isomer of Gossypol that acts as a BH3 mimic capable of binding Bcl-xL and Bcl-2 proteins, with the potential to induce apoptosis and inhibit cell growth.
In vitro
(S)-Gossypol acetic acid inhibits proliferation and induces apoptosis in human nasopharyngeal carcinoma CNE-2 cells in a dose-dependent manner (2.5-20 μM, 24 h). (S)-Gossypol acetic acid decreases mitochondrial membrane potential, upregulates Bax, downregulates Bcl-2, and activates caspase-3[1].
In vivo
In BALB/c nude mice bearing CNE-2 xenograft tumors, intraperitoneal administration of (S)-Gossypol acetic acid at 20 mg/kg/day for 21 days significantly inhibited tumor growth (~60% reduction in volume) without notable weight loss or systemic toxicity[1].
Alias(S)-(+)-Gossypol acetic acid
Chemical Properties
Molecular Weight578.61
FormulaC32H34O10
Cas No.1189561-66-7
SmilesO=CC1=C(O)C(O)=C(C2=CC(=C(C(O)=C12)C3=C(O)C4=C(C=O)C(O)=C(O)C(=C4C=C3C)C(C)C)C)C(C)C.O=C(O)C
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (69.13 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7283 mL8.6414 mL17.2828 mL86.4140 mL
5 mM0.3457 mL1.7283 mL3.4566 mL17.2828 mL
10 mM0.1728 mL0.8641 mL1.7283 mL8.6414 mL
20 mM0.0864 mL0.4321 mL0.8641 mL4.3207 mL
50 mM0.0346 mL0.1728 mL0.3457 mL1.7283 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

Gossypol acetic acidGossypolBcl-2acetic acid(S)-Gossypol acetic acid(S)Gossypol (acetic acid)(S) Gossypol (acetic acid)
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