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Dmt-2'fluoro-da(bz) amidite

🥰Excellent
Catalog No. T36752Cas No. 136834-22-5

Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets and serves as an intermediate in the synthesis of 5'-DMT-3'-phosphoramidite, an antisense compound resistant to nuclease.

Dmt-2'fluoro-da(bz) amidite

Dmt-2'fluoro-da(bz) amidite

🥰Excellent
Purity: 99.17%
Catalog No. T36752Cas No. 136834-22-5
Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets and serves as an intermediate in the synthesis of 5'-DMT-3'-phosphoramidite, an antisense compound resistant to nuclease.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 mg$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.17%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets and serves as an intermediate in the synthesis of 5'-DMT-3'-phosphoramidite, an antisense compound resistant to nuclease.
Chemical Properties
Molecular Weight875.92
FormulaC47H51FN7O7P
Cas No.136834-22-5
SmilesCOc1ccc(cc1)C(OC[C@H]1O[C@H]([C@H](F)[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C)n1cnc2c(NC(=O)c3ccccc3)ncnc12)(c1ccccc1)c1ccc(OC)cc1
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 50 mg/mL (57.08 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2.5 mg/mL (2.85 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1417 mL5.7083 mL11.4166 mL57.0828 mL
5 mM0.2283 mL1.1417 mL2.2833 mL11.4166 mL
10 mM0.1142 mL0.5708 mL1.1417 mL5.7083 mL
20 mM0.0571 mL0.2854 mL0.5708 mL2.8541 mL
50 mM0.0228 mL0.1142 mL0.2283 mL1.1417 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RNASynthesisRNA SynthesisDNASynthesisDNA/RNA SynthesisDNA SynthesisDmt2'fluoroda(bz) amiditeDmt-2'fluoro-da(bz) amiditeDmt 2'fluoro da(bz) amidite
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