This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Bid BH3 (80-99)
Catalog No. T80224 CAS
505070-05-3
Bid BH3 (80-99) is a biologically active peptide known as a pro-apoptotic member of the 'BH3-only' (BOPS) subset within the BCL-2 protein family, pivotal in apoptosis regulation. It notably interacts with Bcl-2, Bax, and Bak, initiating their activation or inactivation, thus inducing cell death. Additionally, Bid translocates from the cytosol to the mitochondrial membrane as part of its functional mechanism. The presence of Pyroglutamyl (pGlu) peptides, which can spontaneously arise from Glutamine (Q) or Glutamic acid (E) at the N-terminus of sequences, is a natural process. The hydrophobic γ-lactam ring of pGlu is theorized to enhance peptide stability, providing resistance to gastrointestinal proteases, making these peptides a recognized variant within peptide analyses, including HPLC purity assessments.
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Bid BH3 (80-99) is a biologically active peptide known as a pro-apoptotic member of the 'BH3-only' (BOPS) subset within the BCL-2 protein family, pivotal in apoptosis regulation. It notably interacts with Bcl-2, Bax, and Bak, initiating their activation or inactivation, thus inducing cell death. Additionally, Bid translocates from the cytosol to the mitochondrial membrane as part of its functional mechanism. The presence of Pyroglutamyl (pGlu) peptides, which can spontaneously arise from Glutamine (Q) or Glutamic acid (E) at the N-terminus of sequences, is a natural process. The hydrophobic γ-lactam ring of pGlu is theorized to enhance peptide stability, providing resistance to gastrointestinal proteases, making these peptides a recognized variant within peptide analyses, including HPLC purity assessments.
Molecular Weight
2309.56
Formula
C95H161N33O32S
CAS No.
505070-05-3
Storage
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.