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A2ti-2

🥰Excellent
Catalog No. T36433Cas No. 482646-13-9
Alias A2ti-2

A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).A2ti-2 exhibits antiviral activity by selectively disrupting protein interactions between A2 and S100A10, and protects against human papillomavirus type 16 (HPV16) infection.

A2ti-2

A2ti-2

🥰Excellent
Purity: 98.31%
Catalog No. T36433Alias A2ti-2Cas No. 482646-13-9
A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).A2ti-2 exhibits antiviral activity by selectively disrupting protein interactions between A2 and S100A10, and protects against human papillomavirus type 16 (HPV16) infection.
Pack SizePriceAvailabilityQuantity
1 mg$98In Stock
5 mg$243In Stock
10 mg$367In Stock
25 mg$715In Stock
50 mg$987In Stock
100 mg$1,360In Stock
500 mg$2,730In Stock
1 mL x 10 mM (in DMSO)$268In Stock
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Batch Information

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Purity:98.31%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).A2ti-2 exhibits antiviral activity by selectively disrupting protein interactions between A2 and S100A10, and protects against human papillomavirus type 16 (HPV16) infection.
Targets&IC50
A2t:230 μM (IC50)
In vitro
A2ti-2 (compound 7a) functions as a blocker of the protein-protein interaction between annexin A2 and S100A10.[1]
A2ti-2 reduction HPV16 PsV infection with <50% achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM.[2]
SynonymsA2ti-2
Chemical Properties
Molecular Weight354.43
FormulaC18H18N4O2S
Cas No.482646-13-9
SmilesCc1ccccc1OCc1nnc(SCC(N)=O)n1-c1ccccc1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (705.36 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8214 mL14.1072 mL28.2143 mL141.0716 mL
5 mM0.5643 mL2.8214 mL5.6429 mL28.2143 mL
10 mM0.2821 mL1.4107 mL2.8214 mL14.1072 mL
20 mM0.1411 mL0.7054 mL1.4107 mL7.0536 mL
50 mM0.0564 mL0.2821 mL0.5643 mL2.8214 mL
100 mM0.0282 mL0.1411 mL0.2821 mL1.4107 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VirusProteaseVirus ProteaseHPVAntiviralA-2ti-2A2ti2A2ti 2
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