Shopping Cart

Your shopping cart is currently empty

A2ti-2

Name: A2ti-2
Brand: TargetMol
SKU: T36433
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T36433Cas No. 482646-13-9

Alias A2ti-2

A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).A2ti-2 exhibits antiviral activity by selectively disrupting protein interactions between A2 and S100A10, and protects against human papillomavirus type 16 (HPV16) infection.

A2ti-2

🥰Excellent

Purity: 99.98%

Catalog No. T36433Alias A2ti-2Cas No. 482646-13-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$243	-	In Stock
10 mg	$367	-	In Stock
25 mg	$715	-	In Stock
50 mg	$987	-	In Stock
100 mg	$1,360	-	In Stock
500 mg	$2,730	-	In Stock
1 mL x 10 mM (in DMSO)	$268	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.98%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).A2ti-2 exhibits antiviral activity by selectively disrupting protein interactions between A2 and S100A10, and protects against human papillomavirus type 16 (HPV16) infection.
Targets&IC50	A2t:230 μM (IC50)
In vitro	A2ti-2 (compound 7a) functions as a blocker of the protein-protein interaction between annexin A2 and S100A10.[1] A2ti-2 reduction HPV16 PsV infection with <50% achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM.[2]
Synonyms	A2ti-2

Chemical Properties

Molecular Weight	354.43
Formula	C₁₈H₁₈N₄O₂S
Cas No.	482646-13-9
Smiles	Cc1ccccc1OCc1nnc(SCC(N)=O)n1-c1ccccc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (705.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8214 mL	14.1072 mL	28.2143 mL	141.0716 mL
5 mM	0.5643 mL	2.8214 mL	5.6429 mL	28.2143 mL
10 mM	0.2821 mL	1.4107 mL	2.8214 mL	14.1072 mL
20 mM	0.1411 mL	0.7054 mL	1.4107 mL	7.0536 mL
50 mM	0.0564 mL	0.2821 mL	0.5643 mL	2.8214 mL
100 mM	0.0282 mL	0.1411 mL	0.2821 mL	1.4107 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc