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K02288

Name: K02288
Brand: TargetMol
SKU: T1914
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T1914Cas No. 1431985-92-0

Alias K 02288

K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.

K02288

🥰Excellent

Purity: 99.83%

Catalog No. T1914Alias K 02288Cas No. 1431985-92-0

K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$52	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$165	In Stock	In Stock
50 mg	$289	In Stock	In Stock
100 mg	$428	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.83%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.
Targets&IC50	ALK6:6.4 nM, ALK1:1.8 nM, ALK3:34.4 nM, ALK2:1.1 nM
In vitro	In zebrafish embryos, K02288 induces dorsal phenotypes in a dose-dependent manner without affecting the formation of intersegmental vessels (ISV).
In vivo	K02288 dose-dependently inhibits Smad1/5/8 phosphorylation induced by BMP4 and BMP6 in C2C12 cells without affecting TGF-β-BMP signaling.
Synonyms	K 02288

Chemical Properties

Molecular Weight	352.38
Formula	C₂₀H₂₀N₂O₄
Cas No.	1431985-92-0
Smiles	COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1cccc(O)c1
Relative Density.	1.232 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 3.5 mg/mL (10 mM)), Heating is recommended.

DMSO: 50 mg/mL (141.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8378 mL	14.1892 mL	28.3785 mL	141.8923 mL
5 mM	0.5676 mL	2.8378 mL	5.6757 mL	28.3785 mL
10 mM	0.2838 mL	1.4189 mL	2.8378 mL	14.1892 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1419 mL	0.7095 mL	1.4189 mL	7.0946 mL
50 mM	0.0568 mL	0.2838 mL	0.5676 mL	2.8378 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	1.4189 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc