Tanomastat

Name: Tanomastat
Brand: TargetMol
SKU: T16986
Rating: 4.5 (1 reviews)

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Catalog No. T16986Cas No. 179545-77-8

Alias BAY 12-9566

Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.

Tanomastat

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Catalog No. T16986Alias BAY 12-9566Cas No. 179545-77-8

Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.

Pack Size	Price	Availability
500 μg	$88	35 days
1 mg	$170	35 days
5 mg	$540	35 days
10 mg	$990	35 days

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Product Introduction

Bioactivity

Description	Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.
Targets&IC50	MMP13:1470 nM （ki）, MMP2:11 nM （ki）, MMP9:301 nM （ki）, MMP3:143 nM （ki）
In vitro	Tanomastat (1-00 μM; 5 days) inhibits tubule formation completely at 15-100 μM. Tanomastat (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC50=840 nM) [2][3].
In vivo	Tanomastat (100 mg/kg; p.o.; daily for a 7-week period) inhibits local tumor regrowth and inhibits the number and volume of lung metastases [3].
Synonyms	BAY 12-9566

Chemical Properties

Molecular Weight	410.91
Formula	C₂₃H₁₉ClO₃S
Cas No.	179545-77-8
Relative Density.	1.33g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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