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STAT5-IN-2

Name: STAT5-IN-2
Brand: TargetMol
SKU: T16940
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16940Cas No. 2111834-61-6

STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).

STAT5-IN-2

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Purity: 99.55%

Catalog No. T16940Cas No. 2111834-61-6

STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	-	In Stock
5 mg	$118	-	In Stock
10 mg	$202	-	In Stock
25 mg	$320	-	In Stock
50 mg	$443	-	In Stock
100 mg	$589	-	In Stock
200 mg	$796	-	In Stock
1 mL x 10 mM (in DMSO)	$130	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.55%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).
Targets&IC50	KU812 cells:5 μM (EC50), K562 cells:9 μM (EC50)
In vitro	STAT5-IN-2 (100 nM-50 µM) inhibits cell growth in KG1a and MV-4-11 cell lines with EC50 values of 2.6 µM and 3.5 µM, respectively. In K562, KU812, KG1a and MV-4-11 cells, STAT5-IN-2 (10 µM) induces apoptosis. In KG1a, MV-4-11 and KU812 cells, STAT5-IN-2 (10 µM) blocks the phosphorylation of STAT5[1].

Chemical Properties

Molecular Weight	397.51
Formula	C₂₆H₂₇N₃O
Cas No.	2111834-61-6
Smiles	CC1(C)CCN(CCOc2ccc3[nH]ccc3c2)c2ccc(cc12)-c1cccnc1
Relative Density.	1.160 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (226.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (8.3 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5157 mL	12.5783 mL	25.1566 mL	125.7830 mL
5 mM	0.5031 mL	2.5157 mL	5.0313 mL	25.1566 mL
10 mM	0.2516 mL	1.2578 mL	2.5157 mL	12.5783 mL
20 mM	0.1258 mL	0.6289 mL	1.2578 mL	6.2891 mL
50 mM	0.0503 mL	0.2516 mL	0.5031 mL	2.5157 mL
100 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc