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TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His)

Catalog No. TMPJ-00276
Synonyms: DR5, TRAILR2, TRICK2, TNFRSF10B, KILLER, TNF-Related Apoptosis-Inducing Ligand Receptor 2, Tumor Necrosis Factor Receptor Superfamily Member 10B, CD262, TRAIL-R2, Death Receptor 5, ZTNFR9, TRAIL Receptor 2

TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 60.00
50 μg 5 days $ 184.00
500 μg 5 days $ 806.00
1 mg 5 days $ 1,060.00
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Biological Description
Technical Params
Product Properties
Description TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
Species Human
Expression System Human Cells
Tag C-Fc-6His
Accession Number O14763
Synonyms DR5, TRAILR2, TRICK2, TNFRSF10B, KILLER, TNF-Related Apoptosis-Inducing Ligand Receptor 2, Tumor Necrosis Factor Receptor Superfamily Member 10B, CD262, TRAIL-R2, Death Receptor 5, ZTNFR9, TRAIL Receptor 2
Amino Acid Ile56-Glu182
Construction Recombinant Human TNF-Related Apoptosis-Inducing Ligand Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ile56-Glu182 is expressed with a human IgG1 Fc, 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 49 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.

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Keywords

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) TRAILR 2 DR5 TRAILR2 CD 262 TRICK2 TRICK 2 TRAILR-2 TNFRSF10B KILLER TNF-Related Apoptosis-Inducing Ligand Receptor 2 DR 5 Tumor Necrosis Factor Receptor Superfamily Member 10B CD262 TRICK-2 DR-5 TRAIL-R2 Death Receptor 5 ZTNFR-9 ZTNFR9 CD-262 ZTNFR 9 TRAIL Receptor 2 recombinant recombinant-proteins proteins protein

 

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