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TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His)
(Synonyms: ZTNFR9, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRICK2, TRAIL-R2, TRAILR2, TRAIL Receptor 2, TNFRSF10B, TNF-Related Apoptosis-Inducing Ligand Receptor 2, KILLER, DR5, Death Receptor 5, CD262) Copy Product InfoSynonyms: ZTNFR9, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRICK2, TRAIL-R2, TRAILR2, TRAIL Receptor 2, TNFRSF10B, TNF-Related Apoptosis-Inducing Ligand Receptor 2, KILLER, DR5, Death Receptor 5, CD262
Catalog No. TMPJ-00276 Copy Product Info
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 49 KDa and the accession number is O14763.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $39 | 35 days | 35 days | |
| 10 µg | $60 | 35 days | 35 days | |
| 20 µg | $96 | 35 days | 35 days | |
| 50 µg | $183 | 35 days | 35 days | |
| 100 µg | $285 | 35 days | 35 days | |
| 200 µg | $445 | 35 days | 35 days | |
| 500 µg | $806 | 35 days | 35 days | |
| 1 mg | $1,060 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 49 KDa and the accession number is O14763. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-hFc-6xHis |
| Accession Number | O14763 |
| Amino Acid | Ile56-Glu182 |
| Construction | Ile56-Glu182 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | ZTNFR9, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRICK2, TRAIL-R2, TRAILR2, TRAIL Receptor 2, TNFRSF10B, TNF-Related Apoptosis-Inducing Ligand Receptor 2, KILLER, DR5, Death Receptor 5, CD262 |
| Research Background | TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B. |
| Molecular Weight | 49 KDa (reducing condition) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) chemical structure | TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) molecular weight
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