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MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

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Catalog No. T39064Cas No. 1599440-25-1

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a degradable ADC linker used for synthesizing ADCs (antibody-drug conjugates).

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

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Purity: 99.73%
Catalog No. T39064Cas No. 1599440-25-1
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a degradable ADC linker used for synthesizing ADCs (antibody-drug conjugates).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$30-In Stock
25 mg$48-In Stock
50 mg$68-In Stock
100 mg$89-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.73%
ee:100%
Appearance:Solid
Color:White
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COA LCMS HNMR CSFC

Product Introduction

Bioactivity
Description
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a degradable ADC linker used for synthesizing ADCs (antibody-drug conjugates).
Chemical Properties
Molecular Weight616.63
FormulaC28H36N6O10
Cas No.1599440-25-1
Smiles[C@H](CC1=CC=CC=C1)(C(NCC(NCOCC(O)=O)=O)=O)NC(CNC(CNC(CCCCCN2C(=O)C=CC2=O)=O)=O)=O
Relative Density.1.341 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80.00 mg/mL (129.74 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6217 mL8.1086 mL16.2172 mL81.0859 mL
5 mM0.3243 mL1.6217 mL3.2434 mL16.2172 mL
10 mM0.1622 mL0.8109 mL1.6217 mL8.1086 mL
20 mM0.0811 mL0.4054 mL0.8109 mL4.0543 mL
50 mM0.0324 mL0.1622 mL0.3243 mL1.6217 mL
100 mM0.0162 mL0.0811 mL0.1622 mL0.8109 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOHMC-Gly-Gly-Phe-Gly-NH-CH-2-O-CH2COOHMCGlyGlyPheGlyNHCH2OCH2COOHMC Gly Gly Phe Gly NH CH2 O CH2COOHADCLinkerADC Linker
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