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BMS-2
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Catalog No. T8326Cas No. 888719-03-7
BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor.
BMS-2
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Purity: 98.33%
Catalog No. T8326Cas No. 888719-03-7
BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $65 | In Stock | In Stock | |
| 2 mg | $95 | In Stock | In Stock | |
| 5 mg | $159 | In Stock | In Stock | |
| 10 mg | $255 | In Stock | In Stock | |
| 25 mg | $478 | In Stock | In Stock | |
| 50 mg | $690 | In Stock | In Stock | |
| 100 mg | $997 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $188 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.33%
Appearance:Solid
Color:White
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Product Introduction
BMS-2 AI Summary
BMS-2 is a potent bioactive small molecule known for its inhibitory effects on various protein targets and signaling pathways. It robustly inhibits MET with an IC50 of 1.8 nM and demonstrates significant antiproliferative activity against Met-dependent human GTL16 cells, having an IC50 of 60.0 nM. Additionally, BMS-2 inhibits Flt3 (IC50 = 4.0 nM), VEGFR2 (IC50 = 4.27 nM), LCK (IC50 = 290.0 nM), and c-Kit (IC50 = 610.0 nM). It also displays antitumor activity with TGI values ranging from 62.0% to 110.0% against GTL16 cells. In terms of drug-like properties, the compound has 100.0% oral bioavailability at a dose of 10 mg/kg in mice, good metabolic stability in both human and mouse liver microsomes, and shows protein binding activity in human and mouse serum. The maximum tolerated dose in mice is 100.0 mg/kg, while the median effective dose is 12.5 mg/kg. Furthermore, BMS-2 exhibits selective inhibition of Plasmodium falciparum proliferation, with IC50 values of 13324.4 nM against the 3D7 strain and 2.7 nM against the DD2 strain. It also displaces fluorescein labeled ATP probes in HTRF assays from proteins such as RIPK3 (IC50 = 180.0 nM) and RIPK1 (IC50 = 1500.0 nM), showing potential as a modulator of cellular pathways involving c-Met, with an IC50 for c-Met displacement of 5.7 nM. Its selectivity indices are substantial for RIPK1 and RIPK2 over RIPK3..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor. |
| Molecular Weight | 458.42 |
| Formula | C25H16F2N4O3 |
| Cas No. | 888719-03-7 |
| Smiles | O(C1=C2C(NC=C2)=NC=C1)C3=C(F)C=C(NC(=O)C=4C(=O)N(C=CC4)C5=CC=C(F)C=C5)C=C3 |
| Relative Density. | 1.41 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.59 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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