Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 78.00 | |
5 mg | 35 days | $ 353.00 | |
10 mg | 35 days | $ 595.00 | |
25 mg | 35 days | $ 1,360.00 |
Description | C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease. |
Synonyms | C2-8 |
Molecular Weight | 510.2 |
Formula | C19H14Br2N2O3S |
CAS No. | 300670-16-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 33 mg/mL
DMSO: 33 mg/mL
DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
You can also refer to dose conversion for different animals. More
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C2-8 300670-16-0 C2 8 C28 C-2-8 inhibitor inhibit