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Picolinamide

Name: Picolinamide
Brand: TargetMol
SKU: T6942
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6942Cas No. 1452-77-3

Alias Picolinoylamide, 2-Pyridinecarboxamide, 2-Picolinamide, 2-Carbamoylpyridine

Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

Picolinamide

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Purity: 99.6%

Catalog No. T6942Alias Picolinoylamide, 2-Pyridinecarboxamide, 2-Picolinamide, 2-CarbamoylpyridineCas No. 1452-77-3

Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

Pack Size	Price	Availability	Quantity
1 g	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.6%

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COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
Targets&IC50	PARP:95 μM
In vitro	In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells. [1]
In vivo	Overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. There is only a small increase (1.5-fold) in renal cortical NAD content after picolinamide treatment[3].
Synonyms	Picolinoylamide, 2-Pyridinecarboxamide, 2-Picolinamide, 2-Carbamoylpyridine

Chemical Properties

Molecular Weight	122.12
Formula	C₆H₆N₂O
Cas No.	1452-77-3
Smiles	NC(=O)C1=NC=CC=C1
Relative Density.	1.2236 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 23 mg/mL (188.34 mM), Sonication is recommended.

DMSO: 45 mg/mL (368.49 mM), Sonication is recommended.

H2O: 22 mg/mL (180.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (16.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	8.1887 mL	40.9433 mL	81.8867 mL	409.4333 mL
5 mM	1.6377 mL	8.1887 mL	16.3773 mL	81.8867 mL
10 mM	0.8189 mL	4.0943 mL	8.1887 mL	40.9433 mL
20 mM	0.4094 mL	2.0472 mL	4.0943 mL	20.4717 mL
50 mM	0.1638 mL	0.8189 mL	1.6377 mL	8.1887 mL
100 mM	0.0819 mL	0.4094 mL	0.8189 mL	4.0943 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc