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Homobutein

Name: Homobutein
Brand: TargetMol
SKU: TN4220
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN4220Cas No. 34000-39-0

Alias 3-O-Methylbutein, 2',4,4'-Trihydroxy-3-methoxychalcone

Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.

Homobutein

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Purity: 99.5%

Catalog No. TN4220Alias 3-O-Methylbutein, 2',4,4'-Trihydroxy-3-methoxychalconeCas No. 34000-39-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$198	-	In Stock
10 mg	$297	-	In Stock
25 mg	$515	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.5%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.
In vitro	Homobutein (1 μg/mL) inhibits the growth of Toxoplasma gondii by 19.48%[1] with IC50s of 15.0 and 16.1 µM for W2 and D6 strains of P. falciparum[2]. Homobutein (20 - 40 μM) inhibits the viability and TNFα-induced NF-κB activity of K562 cells[4].
Synonyms	3-O-Methylbutein, 2',4,4'-Trihydroxy-3-methoxychalcone

Chemical Properties

Molecular Weight	286.28
Formula	C₁₆H₁₄O₅
Cas No.	34000-39-0
Smiles	C(=C/C(=O)C1=C(O)C=C(O)C=C1)\C2=CC(OC)=C(O)C=C2
Relative Density.	1.369 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1mg/mL (insoluble)

DMSO: 100 mg/mL (349.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4931 mL	17.4654 mL	34.9308 mL	174.6542 mL
5 mM	0.6986 mL	3.4931 mL	6.9862 mL	34.9308 mL
10 mM	0.3493 mL	1.7465 mL	3.4931 mL	17.4654 mL
20 mM	0.1747 mL	0.8733 mL	1.7465 mL	8.7327 mL
50 mM	0.0699 mL	0.3493 mL	0.6986 mL	3.4931 mL
100 mM	0.0349 mL	0.1747 mL	0.3493 mL	1.7465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc