DDR2 Protein, Human, Recombinant (aa 422-855, His & GST)

Catalog No. TMPY-04361

DDR2 Protein, Human, Recombinant (aa 422-855, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 77.1 kDa and the accession number is Q16832.

DDR2 Protein, Human, Recombinant (aa 422-855, His & GST)

Catalog No. TMPY-04361

DDR2 Protein, Human, Recombinant (aa 422-855, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 77.1 kDa and the accession number is Q16832.

Pack Size	Price	Availability	Quantity
50 μg	$498	7-10 days

Bulk & Custom

Add to Cart

Questions

Resource Download

User Guide of Recombinant Proteins

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Information

Biological Activity	The specific activity was determined to be 8 nmol/min/mg using synthetic AXLtide peptide(CKKSRGDYMTMQIG) as substrate.
Description	DDR2 Protein, Human, Recombinant (aa 422-855, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 77.1 kDa and the accession number is Q16832.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	His, GST
Accession Number	Q16832
Synonyms	TYRO10,TKT,NTRKR3,MIG20a,discoidin domain receptor tyrosine kinase 2,CD167
Construction	A DNA sequence encoding the human DDR2 (Q16832) (Arg422-Glu855) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. Predicted N terminal: Met
Protein Purity	> 90 % as determined by SDS-PAGE
Molecular Weight	77.1 kDa (predicted); 77 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Shipping with blue ice.
Research Background	Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy