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GW 542573X

Name: GW 542573X
Brand: TargetMol
SKU: T22826
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22826Cas No. 660846-41-3

GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.GW 542573X induces a leftward shift in the Ca2+ response curve of hSK1 from an EC50 (Ca2+) value of 410 nM to 240 nM, which can be used to study neurological disorders.

GW 542573X

🥰Excellent

Purity: 99.91%

Catalog No. T22826Cas No. 660846-41-3

Pack Size	Price	Availability
1 mg	$32	In Stock
5 mg	$77	In Stock
10 mg	$133	In Stock
25 mg	$278	In Stock
50 mg	$463	In Stock
100 mg	$630	In Stock
200 mg	$847	In Stock

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Batch Information

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Purity:99.91%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.GW 542573X induces a leftward shift in the Ca2+ response curve of hSK1 from an EC50 (Ca2+) value of 410 nM to 240 nM, which can be used to study neurological disorders.
In vitro	GW 542573X (100 μM, 200 μM; brain slices from normal rat) was found effective in dose-dependently increasing the interval between seizure-like events.[2]

Chemical Properties

Molecular Weight	364.44
Formula	C₁₉H₂₈N₂O₅
Cas No.	660846-41-3
Smiles	N(C(OCC1CCN(C(OC(C)(C)C)=O)CC1)=O)C2=C(OC)C=CC=C2
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (246.95 mM), Sonication is recommended.

Ethanol: < 36.44 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7439 mL	13.7197 mL	27.4394 mL	137.1968 mL
5 mM	0.5488 mL	2.7439 mL	5.4879 mL	27.4394 mL
10 mM	0.2744 mL	1.3720 mL	2.7439 mL	13.7197 mL
20 mM	0.1372 mL	0.6860 mL	1.3720 mL	6.8598 mL
50 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7439 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3720 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc