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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μg | $258 | In Stock | |
100 μg | $440 | 7-10 days | |
200 μg | $753 | 7-10 days | |
500 μg | $1,530 | 7-10 days |
Biological Information | Testing in progress |
Description | CLEC10A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is Q8IUN9-2. |
Species | Human |
Expression System | HEK293 Cells |
Tag | N-hFc |
Accession Number | Q8IUN9-2 |
Synonyms | HML2,CD301,CLECSF13,HML,MGL,C-type lectin domain family 10, member A,CLECSF14 |
Construction | The Human CLEC10A (Q8IUN9-2) (Gln61-His292) was expressed, with the fused Fc region of Human IgG1 at the N-terminus. |
Protein Purity | > 85 % as determined by SDS-PAGE ![]() |
Molecular Weight | 54.6 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is a type II transmembrane glycoproteins and is expressed on macrophages and related cells of myeloid origins, particularly immature dendritic cells (DCs). There are 2 homologues: MGL1 and MGL2 (CD301a and CD301b) in mice. MGL1/CD301a induces both the production and secretion of interleukin (IL)-10. MGL1/CD301a plays a protective role against colitis by effectively inducing IL-10 production by colonic lamina propria macrophages in response to invading commensal bacteria. |
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