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Samidorphan HCl

Name: Samidorphan HCl
Brand: TargetMol
SKU: T67888L
Price: 167 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67888LCas No. 2328045-02-7

Alias Samidorphan HCl(852626-89-2 free base)

Samidorphan HCl is an orally active and highly potent modulator of the opioid system that binds to μ‐opioid, κ‐opioid, and delta-opioid receptors. Samidorphan HCl is a novel μ-opioid receptor antagonist, a partial agonist for k-opioid and delta-opioid receptors. Samidorphan HCl can be used to prevent and treat schizophrenia.

Samidorphan HCl

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Purity: 97.85%

Catalog No. T67888LAlias Samidorphan HCl(852626-89-2 free base)Cas No. 2328045-02-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$167	In Stock	In Stock
5 mg	$413	In Stock	In Stock
10 mg	$613	-	In Stock
25 mg	$979	-	In Stock
50 mg	$1,320	-	In Stock
100 mg	$1,780	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.85%

Appearance:Solid

Color:Yellow

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Product Introduction

Samidorphan HCl AI Summary

Samidorphan HCl exhibits bioactivity as both an agonist and antagonist at various opioid receptors. It acts as an agonist at the human mu, kappa, and delta opioid receptors, demonstrated by the stimulation of [35S]GTPgammaS binding relative to basal levels, with specific Emax and EC50 values. Additionally, Samidorphan HCl functions as an antagonist by inhibiting [35S]GTPgammaS binding when these receptors are stimulated by certain compounds. The compound also shows different Ki and IC50 values for displacing radioligands from the opioid receptors, indicating its binding affinities and selectivity ratios for the mu, kappa, and delta opioid receptors..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Samidorphan HCl is an orally active and highly potent modulator of the opioid system that binds to μ‐opioid, κ‐opioid, and delta-opioid receptors. Samidorphan HCl is a novel μ-opioid receptor antagonist, a partial agonist for k-opioid and delta-opioid receptors. Samidorphan HCl can be used to prevent and treat schizophrenia.
Synonyms	Samidorphan HCl(852626-89-2 free base)

Chemical Properties

Molecular Weight	406.9
Formula	C₂₁H₂₇ClN₂O₄
Cas No.	2328045-02-7
Smiles	O[C@@]12[C@]3(CC(CC2)=O)C4=C(O)C(C(N)=O)=CC=C4C[C@@]1([H])N(CC3)CC5CC5.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (122.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4576 mL	12.2880 mL	24.5761 mL	122.8803 mL
5 mM	0.4915 mL	2.4576 mL	4.9152 mL	24.5761 mL
10 mM	0.2458 mL	1.2288 mL	2.4576 mL	12.2880 mL
20 mM	0.1229 mL	0.6144 mL	1.2288 mL	6.1440 mL
50 mM	0.0492 mL	0.2458 mL	0.4915 mL	2.4576 mL
100 mM	0.0246 mL	0.1229 mL	0.2458 mL	1.2288 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc