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Macrophage-activating lipopeptide 2 TFA
🥰Excellent
Catalog No. TP2905
Alias MALP-2 TFA
Macrophage-activating lipopeptide-2 TFA is a lipopeptide agonist of Toll-like receptors TLR-2/TLR-6. This compound enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, improving vasodilation. Additionally, Macrophage-activating lipopeptide-2 increases leukocyte adhesion to endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).
Macrophage-activating lipopeptide 2 TFA
Macrophage-activating lipopeptide 2 TFA
🥰Excellent
Catalog No. TP2905Alias MALP-2 TFA
Macrophage-activating lipopeptide-2 TFA is a lipopeptide agonist of Toll-like receptors TLR-2/TLR-6. This compound enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, improving vasodilation. Additionally, Macrophage-activating lipopeptide-2 increases leukocyte adhesion to endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $110 | In Stock | |
| 5 mg | $280 | In Stock | |
| 10 mg | $455 | In Stock | |
| 25 mg | $770 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Macrophage-activating lipopeptide-2 TFA is a lipopeptide agonist of Toll-like receptors TLR-2/TLR-6. This compound enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, improving vasodilation. Additionally, Macrophage-activating lipopeptide-2 increases leukocyte adhesion to endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL). |
| In vitro | Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) enhances the expression of key endothelial adhesion molecules and leukocyte integrin receptors, thereby improving leukocyte endothelial adhesion. Additionally, macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) promotes the phosphorylation of protein kinase B and eNOS in endothelial MyEnd cells, facilitating the release of NO. This compound is also related to macrophage-activating lipopeptide 2 TFA antibodies. |
| In vivo | Macrophage-activating lipopeptide 2, administered intravenously at a dosage of 1 µg dissolved in 125 µL of PBS daily for 10 days, enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL). |
| Alias | MALP-2 TFA |
| Molecular Weight | 2135.56 (free base) |
| Formula | C99H167N19O30S.xC2HF3O2 |
| Sequence | {S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-Gly-Asn-Asn-Asp-Glu-Ser-Asn-Ile-Ser-Phe-Lys-Glu-Lys |
| Sequence Short | {S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-GNNDESNISFKEK |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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