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Macrophage-activating lipopeptide-2 TFA is a lipopeptide agonist of Toll-like receptors TLR-2/TLR-6. This compound enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, improving vasodilation. Additionally, Macrophage-activating lipopeptide-2 increases leukocyte adhesion to endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $110 | In Stock | |
5 mg | $280 | In Stock | |
10 mg | $455 | In Stock | |
25 mg | $770 | In Stock |
Description | Macrophage-activating lipopeptide-2 TFA is a lipopeptide agonist of Toll-like receptors TLR-2/TLR-6. This compound enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, improving vasodilation. Additionally, Macrophage-activating lipopeptide-2 increases leukocyte adhesion to endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL). |
In vitro | Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) enhances the expression of key endothelial adhesion molecules and leukocyte integrin receptors, thereby improving leukocyte endothelial adhesion. Additionally, macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) promotes the phosphorylation of protein kinase B and eNOS in endothelial MyEnd cells, facilitating the release of NO. This compound is also related to macrophage-activating lipopeptide 2 TFA antibodies. |
In vivo | Macrophage-activating lipopeptide 2, administered intravenously at a dosage of 1 µg dissolved in 125 µL of PBS daily for 10 days, enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL). |
Alias | MALP-2 TFA |
Molecular Weight | 2135.56 (free base) |
Formula | C99H167N19O30S.xC2HF3O2 |
Sequence | {S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-Gly-Asn-Asn-Asp-Glu-Ser-Asn-Ile-Ser-Phe-Lys-Glu-Lys |
Sequence Short | {S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-GNNDESNISFKEK |
Storage | keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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