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Macrophage-activating lipopeptide 2 TFA
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Catalog No. TP2905
Alias MALP-2 TFA
Macrophage-activating lipopeptide-2 TFA is a lipopeptide agonist of Toll-like receptors TLR-2/TLR-6. This compound enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, improving vasodilation. Additionally, Macrophage-activating lipopeptide-2 increases leukocyte adhesion to endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).
Macrophage-activating lipopeptide 2 TFA
Macrophage-activating lipopeptide 2 TFA
😃Good
Catalog No. TP2905Alias MALP-2 TFA
Macrophage-activating lipopeptide-2 TFA is a lipopeptide agonist of Toll-like receptors TLR-2/TLR-6. This compound enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, improving vasodilation. Additionally, Macrophage-activating lipopeptide-2 increases leukocyte adhesion to endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).
| Pack Size | Price | Availability | Quantity |
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| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Macrophage-activating lipopeptide-2 TFA is a lipopeptide agonist of Toll-like receptors TLR-2/TLR-6. This compound enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, improving vasodilation. Additionally, Macrophage-activating lipopeptide-2 increases leukocyte adhesion to endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL). |
| In vitro | Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) enhances the expression of key endothelial adhesion molecules and leukocyte integrin receptors, thereby improving leukocyte endothelial adhesion. Additionally, macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) promotes the phosphorylation of protein kinase B and eNOS in endothelial MyEnd cells, facilitating the release of NO. This compound is also related to macrophage-activating lipopeptide 2 TFA antibodies. |
| In vivo | Macrophage-activating lipopeptide 2, administered intravenously at a dosage of 1 µg dissolved in 125 µL of PBS daily for 10 days, enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL). |
| Alias | MALP-2 TFA |
| Molecular Weight | 2135.56 (free base) |
| Formula | C99H167N19O30S.xC2HF3O2 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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