TLR8 agonist 2

Name: TLR8 agonist 2
Brand: TargetMol
SKU: T40039
Rating: 4.5 (1 reviews)

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Catalog No. T40039Cas No. 2412937-64-3

Alias TLR8 agonist 2

TLR8 agonist 2 is a highly effective and specific compound that activates TLR8, possessing an EC 50 of 3 nM in human TLR8. Notably, TLR8 agonist 2 demonstrates lower activity towards human TLR7, with an EC 50 of 33.33 μM.

TLR8 agonist 2

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Catalog No. T40039Alias TLR8 agonist 2Cas No. 2412937-64-3

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Product Introduction

Bioactivity

Description	TLR8 agonist 2 is a highly effective and specific compound that activates TLR8, possessing an EC 50 of 3 nM in human TLR8. Notably, TLR8 agonist 2 demonstrates lower activity towards human TLR7, with an EC 50 of 33.33 μM.
Targets&IC50	TLR7:33.33 μM (EC50), TLR8:3 nM (EC50)
In vitro	TLR8 agonist 2 (Example 1) enhances the production of TNF-α, IL-12p40, IFN-γ, and IFN-α in human peripheral blood mononuclear cells (hPBMC), with EC50 values of 105 nM, 26 nM, 29 nM, and 2800 nM, respectively[1].
In vivo	Pharmacokinetic parameters for TLR8 agonist 2 (Example 1) in mice were determined following intravenous (i.v.) administration at 1 mg/kg and oral (p.o.) administration at 5 mg/kg. The half-life (T 1/2) of TLR8 agonist 2 was observed to be 0.25 hours (i.v.) and 0.5 hours (p.o.), with the area under the curve (AUC) last recorded at 450 ng/mLhr (i.v.) and 624 ng/mLhr (p.o.). The bioavailability (%F) after oral administration was found to be 27.7%[1].
Synonyms	TLR8 agonist 2

Chemical Properties

Molecular Weight	326.408
Formula	C₁₆H₂₂N₈
Cas No.	2412937-64-3
Smiles	CCCC[C@](C)(Cc1nnc[nH]1)Nc1nc(N)nc2cnccc12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc