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2-BFI hydrochloride

🥰Excellent
Catalog No. T22492Cas No. 89196-95-2

2-BFI hydrochloride is a high-affinity agonist of I2-imidazoline receptor. 2-BFI hydrochloride can be used in studies about protection against stroke and acute inflammatory immune disease.

2-BFI hydrochloride

2-BFI hydrochloride

🥰Excellent
Purity: 99.94%
Catalog No. T22492Cas No. 89196-95-2
2-BFI hydrochloride is a high-affinity agonist of I2-imidazoline receptor. 2-BFI hydrochloride can be used in studies about protection against stroke and acute inflammatory immune disease.
Pack SizePriceAvailabilityQuantity
5 mg$53In Stock
10 mg$86In Stock
25 mg$183In Stock
50 mg$295In Stock
100 mg$473In Stock
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Purity:99.94%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
2-BFI hydrochloride is a high-affinity agonist of I2-imidazoline receptor. 2-BFI hydrochloride can be used in studies about protection against stroke and acute inflammatory immune disease.
In vivo
2-BFI hydrochloride administration after dMCAO improved the neurological deficits and decreased the infarct volume. 2-BFI hydrochloride reduced phosphorylation of mTOR and p70S6, increased IL-10 and TGF-β, and decreased IFN-γ levels in ischemic rats. 2-BFI hydrochloride attenuates ischemic injury by inhibiting the activation of mTOR signaling and modulating neuroinflammation after stroke in rats[2].
Chemical Properties
Molecular Weight222.67
FormulaC11H11ClN2O
Cas No.89196-95-2
SmilesCl.N1=C(NCC1)C=2OC=3C=CC=CC3C2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 20 mg/mL (89.82 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM4.4910 mL22.4548 mL44.9095 mL224.5475 mL
5 mM0.8982 mL4.4910 mL8.9819 mL44.9095 mL
10 mM0.4491 mL2.2455 mL4.4910 mL22.4548 mL
20 mM0.2245 mL1.1227 mL2.2455 mL11.2274 mL
50 mM0.0898 mL0.4491 mL0.8982 mL4.4910 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ImidazolineReceptorImidazoline ReceptorI2-imidazoline receptor2-BFI Hydrochloride2BFI hydrochloride2 BFI hydrochloride
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