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BDCA-2 Protein, Cynomolgus, Recombinant (mFc)

(Synonyms: HECL, DLEC, CLECSF7, CLECSF11, CLEC4C, CD303, BDCA-2, BDCA2) Copy Product Info

Synonyms: HECL, DLEC, CLECSF7, CLECSF11, CLEC4C, CD303, BDCA-2, BDCA2

Catalog No. TMPK-00506 Copy Product Info
BDCA-2 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 46.00 kDa and the accession number is A0A2K5UWP4.

Product Introduction

Bioactivity
Bioactivity
Immobilized Cynomolgus BDCA-2, mFc Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-BDCA-2 Antibody, hFc Tag with the EC50 of 13.9ng/ml determined by ELISA.
Description
BDCA-2 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 46.00 kDa and the accession number is A0A2K5UWP4.
Species
Cynomolgus
Expression System
HEK293 Cells
TagN-mFc
Accession NumberA0A2K5UWP4
ConstructionTyr48-Ile212
Protein Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationSupplied as 0.22 μm filtered solution in PBS (pH 7.4).
SynonymsHECL, DLEC, CLECSF7, CLECSF11, CLEC4C, CD303, BDCA-2, BDCA2
Research Background
BDCA-2, BDCA-3, and BDCA-4. In blood, BDCA-2 and BDCA-4 are expressed on CD11c(-) CD123(bright) plasmacytoid dendritic cells, whereas BDCA-3 is expressed on small population of CD11c() CD123(-) dendritic cells. All three Ags are not detectable on a third blood dendritic cell population, which is CD1c() CD11c(bright) CD123(dim), or on any other cells in blood.BDCA-2 is completely down-regulated on plasmacytoid CD11c(-) CD123(bright) dendritic cells, BDCA-2 is rapidly internalized at 37 degrees C after mAb labeling.
Chemical Properties
Molecular Weight46.00 kDa (predicted). Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.
Storage & Solubility Information
ShippingProteins are shipped with blue ice.
StorageIt is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

Related Tags: BDCA-2 Protein, Cynomolgus, Recombinant (mFc) chemical structure | BDCA-2 Protein, Cynomolgus, Recombinant (mFc) molecular weight