Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thalidomide-NH-PEG2-C2-NH-Boc, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon-targeting Thalidomide ligand with a PEG linker for the synthesis of dBRD9 (compound 6). This selective BRD9 probe PROTAC degrader is utilized in researching BAF complex biology.
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Description | Thalidomide-NH-PEG2-C2-NH-Boc, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon-targeting Thalidomide ligand with a PEG linker for the synthesis of dBRD9 (compound 6). This selective BRD9 probe PROTAC degrader is utilized in researching BAF complex biology. |
In vitro | dBRD9, at concentrations ranging from 0 to 1 μM, significantly inhibits cell proliferation, demonstrating effectiveness that is 10 to 100 times greater than that of non-degrading probes[1]. |
Synonyms | Thalidomide-NH-PEG2-C2-NH-Boc |
Molecular Weight | 504.53 |
Formula | C24H32N4O8 |
CAS No. | 2097509-40-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Thalidomide-NH-PEG2-C2-NH-Boc 2097509-40-3 Thalidomide NH PEG2 C2 NH Boc Thalidomide-NH-PEG-2-C2-NH-Boc ThalidomideNHPEG2C2NHBoc inhibitor inhibit