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4-Demethyldeoxypodophyllotoxin
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Catalog No. T83321Cas No. 3590-93-0
4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.
4-Demethyldeoxypodophyllotoxin
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Purity: 99.89%
Catalog No. T83321Cas No. 3590-93-0
4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | - | In Stock | |
| 5 mg | $228 | - | In Stock | |
| 10 mg | $372 | - | In Stock | |
| 25 mg | $613 | - | In Stock | |
| 50 mg | $869 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.89%
Appearance:Solid
Color:White
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Product Introduction
4-Demethyldeoxypodophyllotoxin AI Summary
4-Demethyldeoxypodophyllotoxin exhibits a diverse range of bioactivities with significant cytotoxicity against various human cancer cell lines, including A549 (human lung carcinoma), SK-MEL-2 (human melanoma), HeLa (cervical cancer), and PC3 (prostate cancer). The ED50 and IC50 values for these cell lines range from 0.015 to 3900.0 nM, indicating variable potency. Additionally, it shows notable cytotoxicity against murine sarcoma (S-180) cells with an IC50 of 30.0 nM, inhibits tubulin polymerization with an IC50 of 2000.0 nM, and DNA topoisomerase II with an IC50 of 24500.0 nM in the same cell line. The compound also exhibits immunosuppressive activity with an IC50 of 0.00281 ug/mL in murine splenocytes and displays insecticidal activity against Mythimna separata larvae. Furthermore, it demonstrates antioxidant activity by reducing lipid peroxidation in rat kidney and liver tissues. 4-Demethyldeoxypodophyllotoxin’s partition coefficient (log P) is 2.92, suggesting moderate hydrophobicity. Overall, 4-Demethyldeoxypodophyllotoxin has potential as a multi-target bioactive agent due to its broad-ranging inhibitory and cytotoxic properties..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells. |
| Molecular Weight | 384.38 |
| Formula | C21H20O7 |
| Cas No. | 3590-93-0 |
| Smiles | O=C1[C@@]2([C@@H](C=3C(C[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(O)C(OC)=C5)[H] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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